| Literature DB >> 8078582 |
F Y Tsai1, G Keller, F C Kuo, M Weiss, J Chen, M Rosenblatt, F W Alt, S H Orkin.
Abstract
Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.Entities:
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Year: 1994 PMID： 8078582 DOI： 10.1038/371221a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962