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Literature DB >> 8078471

Escherichia coli mutY-dependent mismatch repair involves DNA polymerase I and a short repair tract.

Abstract

Repair of heteroduplex DNA containing an A/G mismatch in a mutL background requires the Escherichia coli mutY gene function. The mutY-dependent in vitro repair of A/G mismatches is accompanied by repair DNA synthesis on the DNA strand bearing mispaired adenines. The size of the mutY-dependent repair tract was measured by the specific incorporation of alpha-[32P]dCTP into different restriction fragments of the repaired DNA. The repair tract is shorter than 12 nucleotides and longer than 5 nucleotides and is localized to the 3' side of the mismatched adenine. This repair synthesis is carried out by DNA polymerase I.

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Year: 1994 PMID： 8078471 DOI： 10.1007/bf00286698

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

44 in total

Review 1. The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).

Authors: M L Michaels; J H Miller
Journal: J Bacteriol Date: 1992-10 Impact factor: 3.490

2. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants.

Authors: C Rayssiguier; D S Thaler; M Radman
Journal: Nature Date: 1989-11-23 Impact factor: 49.962

3. Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.

Authors: R M Schaaper
Journal: Proc Natl Acad Sci U S A Date: 1988-11 Impact factor: 11.205

4. Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.

Authors: M L Wood; M Dizdaroglu; E Gajewski; J M Essigmann
Journal: Biochemistry Date: 1990-07-31 Impact factor: 3.162

5. Asymmetric repair of bacteriophage T7 heteroduplex DNA.

Authors: J Bauer; G Krämmer; R Knippers
Journal: Mol Gen Genet Date: 1981

6. DNA glycosylase activities for thymine residues damaged by ring saturation, fragmentation, or ring contraction are functions of endonuclease III in Escherichia coli.

Authors: L H Breimer; T Lindahl
Journal: J Biol Chem Date: 1984-05-10 Impact factor: 5.157

7. DNA mismatch correction in a defined system.

Authors: R S Lahue; K G Au; P Modrich
Journal: Science Date: 1989-07-14 Impact factor: 47.728

8. Escherichia coli MutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A.C and A.G mispairs.

Authors: J J Tsai-Wu; H F Liu; A L Lu
Journal: Proc Natl Acad Sci U S A Date: 1992-09-15 Impact factor: 11.205

Escherichia coli mutY-dependent mismatch repair involves DNA polymerase I and a short repair tract.

Review 1. The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).

2. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants.

3. Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.

4. Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.

5. Asymmetric repair of bacteriophage T7 heteroduplex DNA.

6. DNA glycosylase activities for thymine residues damaged by ring saturation, fragmentation, or ring contraction are functions of endonuclease III in Escherichia coli.

7. DNA mismatch correction in a defined system.

8. Escherichia coli MutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A.C and A.G mispairs.

9. The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease.

10. Very short patch mismatch repair in phage lambda: repair sites and length of repair tracts.

1. Repair and mutagenic potency of 8-oxoG:A and 8-oxoG:C base pairs in mammalian cells.

Review 2. DNA repair and genome maintenance in Bacillus subtilis.

3. Hyperrecombination in Streptococcus pneumoniae depends on an atypical mutY homologue.

4. Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein.

5. MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA.