Literature DB >> 8078400

Variance and covariances of the numbers of synonymous and nonsynonymous substitutions per site.

T Ota1, M Nei.   

Abstract

Nei and Gojobori (1986) developed a simple method to estimate the numbers of synonymous (ds) and nonsynonymous (dN) substitutions per site. In the present paper, we have developed a method for computing variances and covariances of ds's and dN's and of the proportions of synonymous (ps) and nonsynonymous (pN) differences. We also have developed a method for computing the variances of mean dS, dN, pS, pN, without constructing a phylogenetic tree of the genes. We have conducted computer simulations based on simple evolutionary models and have shown that the new method gives good estimates of variances and covariances.

Mesh：

Year:  1994        PMID： 8078400     DOI： 10.1093/oxfordjournals.molbev.a040140

Source DB:  PubMed          Journal:  Mol Biol Evol        ISSN： 0737-4038            Impact factor:   16.240


  51 in total

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