| Literature DB >> 8077946 |
R C Rose1, W Bonnez, C Da Rin, D J McCance, R C Reichman.
Abstract
The L1 major capsid protein-coding sequences of human papillomavirus (HPV) types 11, 16 and 18 were expressed in the baculovirus system. Virus-like particles (VLPs) were purified from recombinant-infected Spodoptera frugiperda Sf9 cells and cell-free culture supernatants. Rabbits immunized with purified VLPs developed antibodies that reacted only with the specific VLP type used as the immunogen. In addition, rabbit antibodies raised against infectious HPV-11 virions only reacted with HPV-11 L1 VLPs and not with VLPs derived from either HPV-16 or HPV-18. These results suggest that HPV-11, HPV-16 and HPV-18 virions are antigenically distinct from one another. This observation should be considered in future studies of immune responses to HPV.Entities:
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Year: 1994 PMID： 8077946 DOI： 10.1099/0022-1317-75-9-2445
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891