| Literature DB >> 807736 |
Abstract
The preparation and antimicrobial activity of a series of beta-lactams (3a-f) are described. These compounds were prepared from the 2+2 cycloaddition of beta,beta-disubstituted enamines with aryl isocyanates; compounds 3a-f underwent facile beta-lactam ring fission between aminal carbon atom C4 and the lactam nitrogen N1. The resisting formylacetanilide derivatives were devoid of antibiotic activity.Entities:
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Year: 1975 PMID： 807736 DOI： 10.1021/jm00240a022
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446