| Literature DB >> 8076690 |
T Kobayashi1, S Yamano, S Murayama, H Ishikawa, A Tokumura, T Aono.
Abstract
The effect of lysophosphatidic acid (LPA) on the preimplantation development of mouse embryos was examined. The blastocyst rates from 2-cell and 4-cell stage embryos were significantly higher in the presence of LPA at the pronuclear stage. However, the blastocyst rate from 4-cell stage embryos was significantly lower when LPA was added to the medium at the 4-cell stage than when it was added at the pronuclear stage. Furthermore, pretreatment of pronuclear stage embryos with pertussis toxin suppressed LPA-induced embryo development, suggesting that it is probably mediated by a Gi-protein-linked receptor.Entities:
Mesh：
Substances：
Year: 1994 PMID： 8076690 DOI： 10.1016/0014-5793(94)00815-9
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124