Literature DB >> 8076356

Loss of Y chromosome. An age-related event or a cytogenetic marker of a malignant clone?

D Abeliovich1, O Yehuda, S Ben-Neriah, R Or.   

Abstract

Cytogenetic analysis of bone marrow cells performed at the time of diagnosis of ALL in an 80-year-old male patient revealed two unrelated abnormal clones. One included the 9;22 translocation (Philadelphia chromosome) as the sole aberration and the second was missing the Y chromosome. The significance of this finding in the light of the role of -Y clone in malignancy is discussed.

Entities:  

Mesh：

Year:  1994        PMID： 8076356     DOI： 10.1016/0165-4608(94)90075-2

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  4 in total

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2.  A case of successful management of HHV-8⁺, EBV⁺ germinotropic lymphoproliferative disorder (GLD).

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Journal:  Int J Hematol       Date:  2011-12-14       Impact factor: 2.490

3.  Mosaic loss of chromosome Y is associated with common variation near TCL1A.

Authors:  Weiyin Zhou; Mitchell J Machiela; Neal D Freedman; Nathaniel Rothman; Nuria Malats; Casey Dagnall; Neil Caporaso; Lauren T Teras; Mia M Gaudet; Susan M Gapstur; Victoria L Stevens; Kevin B Jacobs; Joshua Sampson; Demetrius Albanes; Stephanie Weinstein; Jarmo Virtamo; Sonja Berndt; Robert N Hoover; Amanda Black; Debra Silverman; Jonine Figueroa; Montserrat Garcia-Closas; Francisco X Real; Julie Earl; Gaelle Marenne; Benjamin Rodriguez-Santiago; Margaret Karagas; Alison Johnson; Molly Schwenn; Xifeng Wu; Jian Gu; Yuanqing Ye; Amy Hutchinson; Margaret Tucker; Luis A Perez-Jurado; Michael Dean; Meredith Yeager; Stephen J Chanock
Journal:  Nat Genet       Date:  2016-04-11       Impact factor: 38.330

4.  Sex chromosome loss after allogeneic hematopoietic stem cell transplant in patients with hematologic neoplasms: a diagnostic dilemma for clinical cytogeneticists.

Authors:  Zhenya Tang; L Jeffrey Medeiros; C Cameron Yin; Wei Wang; Xinyan Lu; Ken H Young; Joseph D Khoury; Guilin Tang
Journal:  Mol Cytogenet       Date:  2016-08-08       Impact factor: 2.009
  4 in total

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