| Literature DB >> 8075268 |
M J Catalán1, J M Fernández, A Vazquez, E Varela de Seijas, A Suárez, J C Bernaldo de Quirós.
Abstract
To our knowledge, we report the first failure of cefotaxime in the treatment of meningitis due to relatively resistant Streptococcus pneumoniae (MICs of penicillin and cefotaxime, 1 microgram/mL). Cure was achieved with a 14-day course of intravenous and intrathecal vancomycin. We recommend that in cases of meningitis caused by strains of S. pneumoniae for which MICs are > or = 1 microgram/mL, cefotaxime should be used with caution; however, if therapeutic failure is suspected therapy should be changed to intravenous and intrathecal vancomycin.Entities:
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Year: 1994 PMID: 8075268 DOI: 10.1093/clinids/18.5.766
Source DB: PubMed Journal: Clin Infect Dis ISSN: 1058-4838 Impact factor: 9.079