Literature DB >> 807520

The effect of enzyme digestions on the activity of eosinophil chemotactic factor of anaphylaxis (EFC-A).

M K Bach, D G Jones, A B Kay.   

Abstract

Preparations of ECF-A derived from anaphylactic guinea-pig lung diffusates were subjected to a variety of enzymatic degradations. The enzymes employed had specificityonly for their appropiate subtstates. No effect was found following treatmentwith relatively high doses of trypsin, alpha-chymotrypsin, pronase, alkaline phosphataseand sialidase. In contrast a loss of activity was demonstated in a dose-dependent fashion following incubation with tyrosinase, aryl sulphatase and leucine aminopeptidase, suggesting that ECF-A contains a phenolic hydroxyl group, a sulphate ester anda peptide linkage with a free alpha-amino group.

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Year:  1975        PMID： 807520      PMCID： PMC1445822     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  9 in total

1.  Tyrosine-O-sulfate as a constituent of normal human urine.

Authors:  H H TALLAN; S T BELLA; W H STEIN; S MOORE
Journal:  J Biol Chem       Date:  1955-12       Impact factor: 5.157

2.  Purification of neuraminidases from Vibrio Cholerae, Clostridium Perfringens and influenza virus by affinity chromatography.

Authors:  P Cuatrecasas; G Illiano
Journal:  Biochem Biophys Res Commun       Date:  1971-07-02       Impact factor: 3.575

3.  Selective attraction of eosinophils and synergism between eosinophil chemotactic factor of anaphylaxis (ECF-A) and a fragment cleaved from the fifth component of complement (C5a).

Authors:  A B Kay; H S Shin; K F Austen
Journal:  Immunology       Date:  1973-06       Impact factor: 7.397

4.  On the nature of the presumed receptor for IgE on mast cells. I. The effect of sialidase and phospholipase C treatment on the capacity of rat peritoneal cells to participate in IgE-mediated, antigen-induced histamine release in vitro.

Authors:  M K Bach; J R Brashler
Journal:  J Immunol       Date:  1973-06       Impact factor: 5.422

5.  Tumor-associated eosinophilotactic factor.

Authors:  S I Wasserman; E J Goetzl; L Ellman; K F Austen
Journal:  N Engl J Med       Date:  1974-02-21       Impact factor: 91.245

6.  Uptake and subcellular localization of tritiated spermine in Escherichia coli.

Authors:  H G Johnson; M K Bach
Journal:  Arch Biochem Biophys       Date:  1968-10       Impact factor: 4.013

7.  Studies on eosinophil leucocyte migration. II. Factors specifically chemotactic for eosinophils and neutrophils generated from guinea-pig serum by antigen-antibody complexes.

Authors:  A B Kay
Journal:  Clin Exp Immunol       Date:  1970-11       Impact factor: 4.330

8.  Glycoprotein coat of the TA 3 cell. I. Removal of carbohydrate and protein material from viable cells.

Authors:  J F Codington; B H Sanford; R W Jeanloz
Journal:  J Natl Cancer Inst       Date:  1970-10       Impact factor: 13.506

9.  An eosinophil leukocyte chemotactic factor of anaphylaxis.

Authors:  A B Kay; D J Stechschulte; K F Austen
Journal:  J Exp Med       Date:  1971-03-01       Impact factor: 14.307
  9 in total
  2 in total

1.  Studies on the regulation of the neutrophil chemotactic response using a rapid and reliable method for measuring random migration and chemotaxis of neutrophil granulocytes.

Authors:  H U Keller; H Gerber; M W Hess; H Cottier
Journal:  Agents Actions       Date:  1976-02

2.  On the preparation of highly purified slow reacting substance of anaphylaxis (SRS-A) from biological extracts.

Authors:  G J Blackwell; J F Burka; R J Flower; P Torkington
Journal:  Br J Pharmacol       Date:  1980-01       Impact factor: 8.739
  2 in total

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