Literature DB >> 807516

Population and family studies on carbonic anhydrase II polymorphism in Gambia, West Africa.

S Welch.   

Abstract

614 individuals from the village of Keneba in Gambia (West Africa) have been typed for red cell Carbonic Anhydrase II using cellulose acetate electrophoresis followed by detection of the enzyme with the fluorogenic substrate fluorescein diacetate. Three phenotypes were found; 479 CAII 1 (80.94%), 107 CAII 2-1 (17.43%), and 10 CAII 2 (1.63%). The gene frequencies of the 2 autosomal alleles responsible for the electrophoretically distinguishable polymorphism were CAII 1 0.897 and CAII 2 0.103. A study of 72 families confirmed the simple Menedelian co-dominant inheritance.

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Year:  1975        PMID： 807516     DOI： 10.1007/BF00273333

Source DB:  PubMed          Journal:  Humangenetik        ISSN： 0018-7348


  8 in total

1.  Characterization of a new variant of human red cell carbonic anhydrase I, CA If London (Glu-102 leads to Lys).

Authors:  N D Carter; R J Tanis; R E Tashian; R E Ferrell
Journal:  Biochem Genet       Date:  1973-12       Impact factor: 1.890

2.  Human carbonic anhydrases. IX. Inheritance of variant erythrocyte forms.

Authors:  M J Moore; H F Deutsch; F R Ellis
Journal:  Am J Hum Genet       Date:  1973-01       Impact factor: 11.025

3.  The amino acid substitution and some chemical properties of a variant human erythrocyte carbonic anhydrase: carbonic anhydrase Id-Michigan.

Authors:  T B Shows
Journal:  Biochem Genet       Date:  1967-09       Impact factor: 1.890

4.  The detection and differentiation of the products of the human carbonic anhydrase loci, CAI and CAII using fluorogenic substrates.

Authors:  D A Hopkinson; J S Coppock; M F Mühlemann; Y H Edwards
Journal:  Ann Hum Genet       Date:  1974-10       Impact factor: 1.670

5.  Human carbonic anhydrases. 8. Isolation and characterization of polymorphic form of a C type isozyme.

Authors:  K D Lin; H F Deutsch
Journal:  J Biol Chem       Date:  1972-06-25       Impact factor: 5.157

6.  Characterization of two new variants of red cell carbonic anhydrase in the British population: CA Ie Portsmouth and CA Ie Hull.

Authors:  N D Carter; R E Tashian; R G Huntsman; L Sacker
Journal:  Am J Hum Genet       Date:  1972-05       Impact factor: 11.025

7.  Human carbonic anhydrases. VII. A new C type isozyme in erythrocytes of American Negroes.

Authors:  M J Moore; S Funakoshi; H F Deutsch
Journal:  Biochem Genet       Date:  1971-12       Impact factor: 1.890

8.  Human carbonic anhydrases. IV. Properties of a mutant B type isozyme.

Authors:  S Funakoshi; H F Deutsch
Journal:  J Biol Chem       Date:  1970-10-10       Impact factor: 5.157
  8 in total
  7 in total

1.  Human erythrocyte carbonic anhydrase polymorphism in Kenya.

Authors:  A Kendall
Journal:  Hum Genet       Date:  1979-11       Impact factor: 4.132

2.  Serum protein polymorphisms in a village community from the Gambia, West Africa (Hp, Tf, and Gc).

Authors:  S G Welch; C A Swindlehurst; I A McGregor; K Williams
Journal:  Hum Genet       Date:  1979-04-17       Impact factor: 4.132

3.  The red-cell glutamic-pyruvate transaminase, carbonic anhydrase I and II and esterase D polymorphisms in the Ambo populations of South West Africa, with evidence for the existence of an EsDo allele.

Authors:  M P Marks; T Jenkins; G T Nurse
Journal:  Hum Genet       Date:  1977-06-10       Impact factor: 4.132

4.  Isoelectric focusing of human red cell phosphoglucomutase: the distribution of variant phenotypes in a village population from the Gambia, West Africa.

Authors:  S G Welch; C A Swindlehurst; I A McGregor; K Williams
Journal:  Hum Genet       Date:  1978-09-19       Impact factor: 4.132

5.  Relationship between subunit size and number of rare electrophoretic alleles in human enzymes.

Authors:  W F Eanes; R K Koehn
Journal:  Biochem Genet       Date:  1978-10       Impact factor: 1.890

6.  Investigations on the polymorphism of glyoxalase I (EC 4.4.1.5) in the population of Hessen, Germany.

Authors:  P Kühnl; R Schwabenland; W Spielmann
Journal:  Hum Genet       Date:  1977-08-31       Impact factor: 4.132

7.  Alpha 1-antitrypsin (pi) phenotypes in a village population from The Gambia, West Africa. Evidence of a new variant occurring at a polymorphic frequency.

Authors:  S G Welch; I A McGregor; K Williams
Journal:  Hum Genet       Date:  1980-02       Impact factor: 4.132
  7 in total

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