Literature DB >> 8074691

Ribonucleotide reductase: evidence for specific association with HeLa cell mitochondria.

P Young1, J M Leeds, M B Slabaugh, C K Mathews.   

Abstract

Mammalian mitochondria contain pools of deoxyribonucleoside 5'-triphosphates that behave differently from the much larger whole-cell pools. To investigate the origins of these pools, we analyzed HeLa cell mitochondria for ribonucleotide reductase activity. Three findings suggest specific association of a reductase with mitochondria: (1) enzyme activity in extracts of washed mitochondria, (2) stimulation of that activity by dATP at levels inhibitory to the major cellular activity, and (3) association of immunoreactive material with washed and fractionated mitochondria.

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Year:  1994        PMID： 8074691     DOI： 10.1006/bbrc.1994.2146

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

Authors:  Shiwei Song; Zachary F Pursell; William C Copeland; Matthew J Longley; Thomas A Kunkel; Christopher K Mathews
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-22       Impact factor: 11.205

Review 2.  A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells.

Authors:  Vishal V Gandhi; David C Samuels
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2011-05       Impact factor: 1.381

3.  Expression and maintenance of mitochondrial DNA: new insights into human disease pathology.

Authors:  Gerald S Shadel
Journal:  Am J Pathol       Date:  2008-05-05       Impact factor: 4.307

4.  POS5 gene of Saccharomyces cerevisiae encodes a mitochondrial NADH kinase required for stability of mitochondrial DNA.

Authors:  Micheline K Strand; Gregory R Stuart; Matthew J Longley; Maria A Graziewicz; Olivia C Dominick; William C Copeland
Journal:  Eukaryot Cell       Date:  2003-08

Review 5.  Mouse models of oxidative phosphorylation defects: powerful tools to study the pathobiology of mitochondrial diseases.

Authors:  Alessandra Torraco; Francisca Diaz; Uma D Vempati; Carlos T Moraes
Journal:  Biochim Biophys Acta       Date:  2008-06-13

6.  Ribonucleotide reductase association with mammalian liver mitochondria.

Authors:  Korakod Chimploy; Shiwei Song; Linda J Wheeler; Christopher K Mathews
Journal:  J Biol Chem       Date:  2013-03-15       Impact factor: 5.157

7.  Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication.

Authors:  Vishal V Gandhi; David C Samuels
Journal:  PLoS Comput Biol       Date:  2011-08-04       Impact factor: 4.475

8.  Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice.

Authors:  E Arpaia; P Benveniste; A Di Cristofano; Y Gu; I Dalal; S Kelly; M Hershfield; P P Pandolfi; C M Roifman; A Cohen
Journal:  J Exp Med       Date:  2000-06-19       Impact factor: 14.307

9.  Deferiprone targets aconitase: implication for Friedreich's ataxia treatment.

Authors:  Sergio Goncalves; Vincent Paupe; Emmanuel P Dassa; Pierre Rustin
Journal:  BMC Neurol       Date:  2008-06-16       Impact factor: 2.474

10.  MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.

Authors:  Ilaria Dalla Rosa; Yolanda Cámara; Romina Durigon; Chloe F Moss; Sara Vidoni; Gokhan Akman; Lilian Hunt; Mark A Johnson; Sarah Grocott; Liya Wang; David R Thorburn; Michio Hirano; Joanna Poulton; Robert W Taylor; Greg Elgar; Ramon Martí; Peter Voshol; Ian J Holt; Antonella Spinazzola
Journal:  PLoS Genet       Date:  2016-01-13       Impact factor: 5.917
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