| Literature DB >> 8073085 |
S Nagae1, M Ushijima, S Hatono, J Imai, S Kasuga, H Matsuura, Y Itakura, Y Higashi.
Abstract
The pharmacokinetic behavior of S-allylcysteine (SAC), one of the biologically active transformation products from garlic, was investigated after oral administration to rats, mice, and dogs. SAC was rapidly and easily absorbed in the gastrointestinal tract and distributed mainly in plasma, liver, and kidney. The bioavailability was 98.2, 103.0, and 87.2% in rats, mice, and dogs, respectively. SAC was mainly excreted into urine in the N-acetyl form in rats; however, mice excreted both SAC and the N-acetyl form. The half-life of SAC was longer in dogs than in rats and mice.Entities:
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Year: 1994 PMID： 8073085 DOI： 10.1055/s-2006-959461
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352