Literature DB >> 8072542

A genome-wide search for human type 1 diabetes susceptibility genes.

J L Davies1, Y Kawaguchi, S T Bennett, J B Copeman, H J Cordell, L E Pritchard, P W Reed, S C Gough, S C Jenkins, S M Palmer.   

Abstract

We have searched the human genome for genes that predispose to type 1 (insulin-dependent) diabetes mellitus using semi-automated fluorescence-based technology and linkage analysis. In addition to IDDM1 (in the major histocompatibility complex on chromosome 6p21) and IDDM2 (in the insulin gene region on chromosome 11p15), eighteen different chromosome regions showed some positive evidence of linkage to disease. Linkages to chromosomes 11q (IDDM4) and 6q (IDDM5) were confirmed by replication, and chromosome 18 may encode a fifth disease locus. There are probably no genes with large effects aside from IDDM1. Therefore polygenic inheritance is indicated, with a major locus at the major histocompatibility complex.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8072542     DOI： 10.1038/371130a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  234 in total

1.  On a randomization procedure in linkage analysis.

Authors:  H Zhao; K R Merikangas; K K Kidd
Journal:  Am J Hum Genet       Date:  1999-11       Impact factor: 11.025

Review 2.  Genetic predisposition to IDDM.

Authors:  S Caillat-Zucman; J F Bach
Journal:  Clin Rev Allergy Immunol       Date:  2000-12       Impact factor: 8.667

Review 3.  T-cell reactivity to beta-cell antigens in human insulin-dependent (type 1) diabetes mellitus. Implications for diagnosis and therapy.

Authors:  B O Roep
Journal:  Clin Rev Allergy Immunol       Date:  2000-12       Impact factor: 8.667

Review 4.  The genetics of type 2 diabetes.

Authors:  M McCarthy; S Menzel
Journal:  Br J Clin Pharmacol       Date:  2001-03       Impact factor: 4.335

5.  Age and sex based genetic locus heterogeneity in type 1 diabetes.

Authors:  A D Paterson; A Petronis
Journal:  J Med Genet       Date:  2000-03       Impact factor: 6.318

6.  Multilocus linkage tests based on affected relative pairs.

Authors:  H J Cordell; G C Wedig; K B Jacobs; R C Elston
Journal:  Am J Hum Genet       Date:  2000-03-21       Impact factor: 11.025

Review 7.  Gene mapping by linkage and association analysis.

Authors:  R E March
Journal:  Mol Biotechnol       Date:  1999-12-01       Impact factor: 2.695

8.  Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.

Authors:  N J Cox; B Wapelhorst; V A Morrison; L Johnson; L Pinchuk; R S Spielman; J A Todd; P Concannon
Journal:  Am J Hum Genet       Date:  2001-08-15       Impact factor: 11.025

9.  Genomewide scans of complex human diseases: true linkage is hard to find.

Authors:  J Altmüller; L J Palmer; G Fischer; H Scherb; M Wjst
Journal:  Am J Hum Genet       Date:  2001-09-14       Impact factor: 11.025

Review 10.  B cell inhibitory receptors and autoimmunity.

Authors:  Nicholas R Pritchard; Kenneth G C Smith
Journal:  Immunology       Date:  2003-03       Impact factor: 7.397
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.