Literature DB >> 8072495

PKA controls a level of topoisomerase I mRNA in mouse L5178Y lymphoma cells treated with db-cAMP.

R M Czerwinski1, K Nieznanski, B Sochanowicz, K Staron.   

Abstract

The level of topoisomerase I mRNA was measured in cells of two mouse lymphoma (LY) sublines treated with db-cAMP. A transient increase of the level was observed to be of about 60% of the basic level and to have maximum after the 3 h treatment of LY-S cells. The increase in LY-R subline was two-fold lower. The activity of PKA in a cytosol fraction of LY-S cells was 1.75 times higher than that in LY-R cells. The activity of PKA in membranes and nuclear fraction did not differ significantly in both cell types. When the activity of PKA in LY-S cells was inhibited with H8, no increase of the level of topoisomerase I mRNA was observed upon db-cAMP treatment of cells. We suggest that the activity of PKA in the cytosol controls the expression of topoisomerase I gene in LY cells at high concentration of cAMP.

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Year:  1994        PMID： 8072495     DOI： 10.1007/bf00997153

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  27 in total

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4.  Monoclonal antibodies neutralizing mammalian DNA topoisomerase I activity.

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5.  Characterization of deoxyribonucleic acid synthesis in reconstituted nuclear systems.

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6.  Regulation of c-jun gene expression by cAMP in HL-60 myeloid leukemia cells.

Authors:  T Nakamura; R Datta; M L Sherman; D Kufe
Journal:  J Biol Chem       Date:  1990-12-15       Impact factor: 5.157

7.  Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR).

Authors:  D R Cool; F H Leibach; V K Bhalla; V B Mahesh; V Ganapathy
Journal:  J Biol Chem       Date:  1991-08-25       Impact factor: 5.157

8.  Phorbol ester transiently increases topoisomerase I mRNA levels in human skin fibroblasts.

Authors:  C L Hwong; M S Chen; J L Hwang
Journal:  J Biol Chem       Date:  1989-09-05       Impact factor: 5.157

9.  cAMP regulates transcription of the alpha 2A adrenergic receptor gene in HT-29 cells.

Authors:  M Sakaue; B B Hoffman
Journal:  J Biol Chem       Date:  1991-03-25       Impact factor: 5.157

10.  Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

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