| Literature DB >> 8072436 |
Abstract
Alzheimer disease is typified by the accumulation of protein and neuronal death. We propose that neuronal death creates a proteolytic imbalance that generates the pathological lesions. Our hypothesis explains the morphology and topographic distribution of neuritic plaques and neurofibrillary tangles.Entities:
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Year: 1994 PMID： 8072436 DOI： 10.1016/0306-9877(94)90132-5
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538