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Literature DB >> 8071970

The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.

M D Teare¹, K Rohde, M F Santibáñez Koref.

Abstract

A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.

Entities: Disease

Mesh：

Year: 1994 PMID： 8071970 PMCID： PMC1049921 DOI： 10.1136/jmg.31.6.448

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

10 in total

1. Loss of heterozygosity, chromosome 7q, and breast cancer.

Authors: C J Cornelisse
Journal: Lancet Date: 1992-06-06 Impact factor: 79.321

2. Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients.

Authors: E D Lustbader; W R Williams; M L Bondy; S Strom; L C Strong
Journal: Am J Hum Genet Date: 1992-08 Impact factor: 11.025

3. p53 germline mutations in Li-Fraumeni syndrome.

Authors: M F Santibáñez-Koref; J M Birch; A L Hartley; P H Jones; A W Craft; T Eden; D Crowther; A M Kelsey; M Harris
Journal: Lancet Date: 1991-12-14 Impact factor: 79.321

4. Allelotype of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q.

Authors: P Devilee; M van Vliet; P van Sloun; N Kuipers Dijkshoorn; J Hermans; P L Pearson; C J Cornelisse
Journal: Oncogene Date: 1991-09 Impact factor: 9.867

5. Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM region on 17q21.3 often and commonly deleted in tumors.

Authors: H Saito; J Inazawa; S Saito; F Kasumi; S Koi; S Sagae; R Kudo; J Saito; K Noda; Y Nakamura
Journal: Cancer Res Date: 1993-07-15 Impact factor: 12.701

6. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors: D F Easton; D T Bishop; D Ford; G P Crockford
Journal: Am J Hum Genet Date: 1993-04 Impact factor: 11.025

7. Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer.

Authors: I Bièche; M H Champème; F Matifas; K Hacène; R Callahan; R Lidereau
Journal: Lancet Date: 1992-01-18 Impact factor: 79.321

8. Mutation and cancer: statistical study of retinoblastoma.

Authors: A G Knudson
Journal: Proc Natl Acad Sci U S A Date: 1971-04 Impact factor: 11.205

9. Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome.

Authors: S A Smith; D F Easton; D G Evans; B A Ponder
Journal: Nat Genet Date: 1992-10 Impact factor: 38.330

10. Heterogeneity of subcellular localization of p53 protein in human glioblastomas.

Authors: I U Ali; J B Schweitzer; B Ikejiri; A Saxena; J T Robertson; E H Oldfield
Journal: Cancer Res Date: 1994-01-01 Impact factor: 12.701

10 in total

6 in total

The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.

1. Loss of heterozygosity, chromosome 7q, and breast cancer.

2. Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients.

3. p53 germline mutations in Li-Fraumeni syndrome.

4. Allelotype of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q.

5. Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM region on 17q21.3 often and commonly deleted in tumors.

6. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

7. Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer.

8. Mutation and cancer: statistical study of retinoblastoma.

9. Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome.

10. Heterogeneity of subcellular localization of p53 protein in human glioblastomas.

Review 1. Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives.

2. Using Somatic Mutations from Tumors to Classify Variants in Mismatch Repair Genes.

Review 3. Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.

4. An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.

Review 5. Detecting low penetrance genes in cancer: the way ahead.

6. Mutational analysis of BRCA1 gene in ovarian and breast-ovarian cancer families in Japan.