Literature DB >> 8069682

Dual regulation by opioids of 3H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH.

O Keren1, M Garty, Y Sarne.   

Abstract

Depolarization-evoked 3H-norepinephrine release from SK-N-SH cells was found to be regulated by opioid ligands. Opioids exerted either inhibition or augmentation of 3H-norepinephrine release. Both effects were mediated by opioid receptors. In addition, a nonopioid inhibitory effect of opiates on release was observed. The SK-N-SH cell-line provides a suitable model for studying the various mechanisms underlying the opioid regulatory pathways within single cells.

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Year:  1994        PMID： 8069682     DOI： 10.1016/0006-8993(94)90098-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  2 in total

1.  Opioid receptor and calcium channel regulation of adenylyl cyclase, modulated by GM1, in NG108-15 cells: competitive interactions.

Authors:  G Wu; Z H Lu; P Alfinito; R W Ledeen
Journal:  Neurochem Res       Date:  1997-10       Impact factor: 3.996

Review 2.  Stimulatory effects of opioids on transmitter release and possible cellular mechanisms: overview and original results.

Authors:  Y Sarne; A Fields; O Keren; M Gafni
Journal:  Neurochem Res       Date:  1996-11       Impact factor: 3.996
  2 in total

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