Literature DB >> 8069675

Modulation of cortical neuronal activity by a serotonergic agent: a PET study in humans.

S Kapur1, J Meyer, A A Wilson, S Houle, G M Brown.   

Abstract

This study investigates the effect of a serotonergic agent, fenfluramine, on neuronal activity, as measured using [18F]fluorodeoxyglucose (FDG) uptake with positron emission tomography (PET) in humans. Eleven subjects each received oral fenfluramine and placebo, on two different occasions, followed by FDG PET scans. Our study shows that fenfluramine modulates ongoing neuronal activity in a regionally specific fashion with a relative increase in metabolism in the prefrontal cortex and a relative decrease in the occipital-temporal regions.

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Year:  1994        PMID： 8069675     DOI： 10.1016/0006-8993(94)90091-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  3 in total

1.  Dextroamphetamine enhances "neural network-specific" physiological signals: a positron-emission tomography rCBF study.

Authors:  V S Mattay; K F Berman; J L Ostrem; G Esposito; J D Van Horn; L B Bigelow; D R Weinberger
Journal:  J Neurosci       Date:  1996-08-01       Impact factor: 6.167

Review 2.  Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its congeners.

Authors:  G Huether; D Zhou; E Rüther
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

3.  Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine.

Authors:  D P Holschneider; O U Scremin; L Huynh; K Chen; I Seif; J C Shih
Journal:  Neuroscience       Date:  2000       Impact factor: 3.590
  3 in total

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