Bilateral imbalance in striatal DA-uptake controls rotation behavior.

We tested the relation between bilateral imbalance in striatal DA uptake and asymmetric rotation behavior. Rats were screened for either spontaneous or amphetamine-induced preferred direction of rotation and the presynaptic DA transporter in the ipsi- and contralateral striatum was characterized in vitro by measuring [3H]DA uptake or [3H]GBR-12935 binding. DA uptake was lower in the striatum contralateral to either the spontaneous or amphetamine-induced preferred direction of rotation. Similar imbalance in the density of the transporter was confirmed by the binding experiments. These results support the hypothesis that striatal imbalance in DA uptake produces asymmetric behavior during spontaneous rotation. Further studies are required to assess the involvement of DA transporter imbalance in amphetamine-induced behavioral asymmetry.