Literature DB >> 8068174

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes.

A Rao1.   

Abstract

The transcription factor NF-ATp is a target in activated T cells for the calcium-regulated phosphatase calcineurin, and is therefore a secondary target for the immunosuppressive drugs cyclosporin A and FK506. Here, Anjana Rao describes how NF-ATp cooperates with Fos- and Jun-family proteins to mediate transcription of the interleukin 2 gene, and how it may participate in the calcium-dependent transcription of other cytokine genes in several types of immune-system cells.

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Year:  1994        PMID： 8068174     DOI： 10.1016/0167-5699(94)90007-8

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  94 in total

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