| Literature DB >> 8064664 |
A S Hammer1, M A Carothers, C L Harris, D A O'Keefe, R D Ayl, J L Peterson, K A Shank, C G Couto.
Abstract
An inexpensive combination chemotherapy protocol containing cyclophosphamide, dactinomycin, and 5-fluorouracil was evaluated in dogs with carcinomas. Fifteen dogs were entered in this study, and there were 1 complete response and 2 partial responses among 12 evaluable dogs. However, 6 of 15 dogs (40%) developed neurotoxicity. The neurotoxicity of this protocol was compared with a previous 5-fluorouracil-containing protocol and found to be significantly higher. Due to the unacceptably high rate of neurotoxicity, this protocol cannot be recommended for use in dogs with cancer.Entities:
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Year: 1994 PMID： 8064664 DOI： 10.1111/j.1939-1676.1994.tb03225.x
Source DB: PubMed Journal: J Vet Intern Med ISSN： 0891-6640 Impact factor: 3.333