Literature DB >> 8064290

Genetically engineered synthesis of natural products.

A I Scott1.   

Abstract

The feasibility of multi-step, one-flask total synthesis of natural products is demonstrated by cloning and overexpression of the corresponding biosynthetic enzymes from plant and microbial sources. As many as eight or nine enzymes can be recombined in vitro to reach an advanced intermediate in the vitamin B12 pathway.

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Year:  1994        PMID： 8064290     DOI： 10.1021/np50107a001

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  3 in total

1.  Finding the final pieces of the vitamin B12 biosynthetic jigsaw.

Authors:  Martin J Warren
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-27       Impact factor: 11.205

2.  Regeneration of patchouli (Pogostemon cablin Benth.) plants from leaf and node callus, and evaluation after growth in the field.

Authors:  M Misra
Journal:  Plant Cell Rep       Date:  1996-09       Impact factor: 4.570

3.  Pathway engineered enzymatic de novo purine nucleotide synthesis.

Authors:  Heather L Schultheisz; Blair R Szymczyna; Lincoln G Scott; James R Williamson
Journal:  ACS Chem Biol       Date:  2008-08-15       Impact factor: 5.100
  3 in total

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