Literature DB >> 8063607

Spontaneous renal cell tumors in Long-Evans Cinnamon rats.

K Izumi1, K Kitaura, Y Chone, H Tate, T Nakagawa, Y Suzuki, K Matsumoto.   

Abstract

Neoplastic lesions of the kidneys in untreated Long-Evans Cinnamon (LEC) rats of 57-118 weeks old (85 males and 34 females) and male F344 rats of 64-93 weeks old (59 males) were examined histologically. The incidences of renal cell tumors in male and female LEC rats were 6/80 (8%) in weeks 57-65, 3/19 (16%) in weeks 66-75, 3/8 (38%) in weeks 76-105 and 7/12 (58%) in weeks 106-118. Of these tumors, 13 were microscopic adenomas and 7 were renal cell carcinomas. The copper content of the kidneys was about three times higher in LEC rats than in F344 rats (P < 0.001), but the iron content of the kidneys was similar in the two strains.

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Mesh：

Year:  1994        PMID： 8063607      PMCID： PMC5919523          DOI： 10.1111/j.1349-7006.1994.tb02396.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  13 in total

1.  Neoplastic and nonneoplastic lesions in aging Osborne-Mendel rats.

Authors:  D G Goodman; J M Ward; R A Squire; M B Paxton; W D Reichardt; K C Chu; M S Linhart
Journal:  Toxicol Appl Pharmacol       Date:  1980-09-30       Impact factor: 4.219

2.  Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease.

Authors:  Y Li; Y Togashi; S Sato; T Emoto; J H Kang; N Takeichi; H Kobayashi; Y Kojima; Y Une; J Uchino
Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

3.  High copper and iron levels and expression of Mn-superoxide dismutase in mutant rats displaying hereditary hepatitis and hepatoma (LEC rats).

Authors:  K Suzuki; N Miyazawa; T Nakata; H G Seo; T Sugiyama; N Taniguchi
Journal:  Carcinogenesis       Date:  1993-09       Impact factor: 4.944

4.  Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic considerations.

Authors:  D N McMartin; P S Sahota; D E Gunson; H H Hsu; R H Spaet
Journal:  Toxicol Pathol       Date:  1992       Impact factor: 1.902

5.  Spontaneous tumors in F-344/DuCrj rats.

Authors:  A Maekawa; Y Kurokawa; M Takahashi; T Kokubo; T Ogiu; H Onodera; H Tanigawa; Y Ohno; F Furukawa; Y Hayashi
Journal:  Gan       Date:  1983-06

6.  Natural history of body weight gain, survival, and neoplasia in the F344 rat.

Authors:  H A Solleveld; J K Haseman; E E McConnell
Journal:  J Natl Cancer Inst       Date:  1984-04       Impact factor: 13.506

7.  New mutation causing hereditary hepatitis in the laboratory rat.

Authors:  M C Yoshida; R Masuda; M Sasaki; N Takeichi; H Kobayashi; K Dempo; M Mori
Journal:  J Hered       Date:  1987 Nov-Dec       Impact factor: 2.645

8.  Spontaneous renal neoplasms in rats.

Authors:  M Chandra; M G Riley; D E Johnson
Journal:  J Appl Toxicol       Date:  1993 Mar-Apr       Impact factor: 3.446

9.  Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.

Authors:  O Hino; A J Klein-Szanto; J J Freed; J R Testa; D Q Brown; M Vilensky; R S Yeung; K D Tartof; A G Knudson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205

10.  High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis.

Authors:  R Masuda; M C Yoshida; M Sasaki; K Dempo; M Mori
Journal:  Jpn J Cancer Res       Date:  1988-07
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  4 in total

1.  Role of copper accumulation in spontaneous renal carcinogenesis in Long-Evans Cinnamon rats.

Authors:  K Kitaura; Y Chone; N Satake; A Akagi; T Ohnishi; Y Suzuki; K Izumi
Journal:  Jpn J Cancer Res       Date:  1999-04

2.  Low susceptibility of Long-Evans Cinnamon rats to N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder carcinogenesis and inhibitory effect of urinary copper.

Authors:  Y Chone; T Kinouchi; T Yamada; Y Suzuki; K Kitaura; Z Jiao; T Minami; Y Bando; H Uehara; M Mochizuki; Y Ohnishi; K Izumi
Journal:  Jpn J Cancer Res       Date:  2000-01

3.  Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.

Authors:  T Minami; S Kaneda; T Otsuka; Z Jiao; Y Suzuki; T Yamada; K Matsumoto; K Izumi
Journal:  Jpn J Cancer Res       Date:  2001-08

Review 4.  Disease Overview of the Urinary Tract in Exotic Companion Mammals and Tips on Clinical Management.

Authors:  Drury R Reavill; Angela M Lennox
Journal:  Vet Clin North Am Exot Anim Pract       Date:  2020-01
  4 in total

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