OBJECTIVE: To compare the efficacy of a resorbable hydrogel material with oxidized regenerated cellulose and hyaluronic acid in an ovarian adhesion model. DESIGN: Controlled, blinded, and randomized study involving female rabbits. SETTING: Academic research environment. INTERVENTIONS: A water-soluble hydrogen precursor was applied to the ovary as a liquid and converted to a hydrogel by exposure to long wavelength ultraviolet light, a 0.4% solution of hyaluronic acid was applied to the ovary, or an oxidized regenerated cellulose patch was applied to the ovary after wedge resectioning. MAIN OUTCOME MEASURES: Extent and severity of adhesion formation. RESULTS: Application of the hydrogel reduced adhesion formation by 88%. Neither oxidized regenerated cellulose nor hyaluronic acid reduced adhesion formation. CONCLUSION: The photopolymerized, resorbable hydrogel material is highly effective for the reduction of periovarian adhesions in this model.
OBJECTIVE: To compare the efficacy of a resorbable hydrogel material with oxidized regenerated cellulose and hyaluronic acid in an ovarian adhesion model. DESIGN: Controlled, blinded, and randomized study involving female rabbits. SETTING: Academic research environment. INTERVENTIONS: A water-soluble hydrogen precursor was applied to the ovary as a liquid and converted to a hydrogel by exposure to long wavelength ultraviolet light, a 0.4% solution of hyaluronic acid was applied to the ovary, or an oxidized regenerated cellulose patch was applied to the ovary after wedge resectioning. MAIN OUTCOME MEASURES: Extent and severity of adhesion formation. RESULTS: Application of the hydrogel reduced adhesion formation by 88%. Neither oxidized regenerated cellulose nor hyaluronic acid reduced adhesion formation. CONCLUSION: The photopolymerized, resorbable hydrogel material is highly effective for the reduction of periovarian adhesions in this model.
Authors: Bernhard Kraemer; Christian Wallwiener; Taufiek K Rajab; Christoph Brochhausen; Markus Wallwiener; Ralf Rothmund Journal: Biomed Res Int Date: 2014-04-08 Impact factor: 3.411