Literature DB >> 8062214

Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1.

N Tanaka1, M Ishihara, T Taniguchi.   

Abstract

The transcriptional activator IRF-1 and its antagonistic repressor IRF-2 are regulators of the interferon (IFN) system and of cell growth. Overexpression of IRF-2 leads to transformation of NIH3T3 cells, and the concomitant overexpression of IRF-1 reverts this transformed phenotype. Here we report that c-myc- or fosB-transformed rat embryonic fibroblast cells can be reverted by the introduction of the IRF-1 gene. Thus, the anti-oncogenic function of IRF-1 is not limited to only IRF-2 overexpressing cells, suggesting the broad role of IRF-1 as a tumor suppressor.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8062214     DOI： 10.1016/0304-3835(94)90318-2

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  20 in total

Review 1.  Molecular biology of KSHV in relation to AIDS-associated oncogenesis.

Authors:  Whitney Greene; Kurt Kuhne; Fengchun Ye; Jiguo Chen; Fuchun Zhou; Xiufen Lei; Shou-Jiang Gao
Journal:  Cancer Treat Res       Date:  2007

2.  Identification of a natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression.

Authors:  Jinbo Gao; Yujun Wang; Quanhua Xing; Jin Yan; Maheswari Senthil; Yasir Akmal; Claudia M Kowolik; Julia Kang; David M Lu; Ming Zhao; Zhixiu Lin; Christopher H K Cheng; M L Richard Yip; John H Yim
Journal:  Mol Cancer Ther       Date:  2011-08-04       Impact factor: 6.261

3.  Recombinant human interferon regulatory factor-1 (IRF-1) protein expression and solubilisation study in Escherichia coli.

Authors:  Kumar Mishra Santosh; Kumar Nitish; Kumar Gautam; Kashav Tara; Prakash Krishna
Journal:  Mol Biol Rep       Date:  2018-08-16       Impact factor: 2.316

4.  Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/β-catenin signaling in colorectal cancer cells.

Authors:  Tomoyuki Ohsugi; Kiyoshi Yamaguchi; Chi Zhu; Tsuneo Ikenoue; Kiyoko Takane; Masaru Shinozaki; Giichiro Tsurita; Hideaki Yano; Yoichi Furukawa
Journal:  Oncogene       Date:  2019-07-10       Impact factor: 9.867

5.  Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors.

Authors:  S Jayachandra; K G Low; A E Thlick; J Yu; P D Ling; Y Chang; P S Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

6.  Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53.

Authors:  H Nozawa; E Oda; K Nakao; M Ishihara; S Ueda; T Yokochi; K Ogasawara; Y Nakatsuru; S Shimizu; Y Ohira; K Hioki; S Aizawa; T Ishikawa; M Katsuki; T Muto; T Taniguchi; N Tanaka
Journal:  Genes Dev       Date:  1999-05-15       Impact factor: 11.361

7.  IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition.

Authors:  Michaele J Armstrong; Michael T Stang; Ye Liu; Jin Yan; Eva Pizzoferrato; John H Yim
Journal:  Cancer Biol Ther       Date:  2015       Impact factor: 4.742

8.  Tumor suppressive protein gene associated with retinoid-interferon-induced mortality (GRIM)-19 inhibits src-induced oncogenic transformation at multiple levels.

Authors:  Sudhakar Kalakonda; Shreeram C Nallar; Ping Gong; Daniel J Lindner; Simeon E Goldblum; Sekhar P Reddy; Dhananjaya V Kalvakolanu
Journal:  Am J Pathol       Date:  2007-09-06       Impact factor: 4.307

9.  Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL.

Authors:  Nicole Clarke; Ana M Jimenez-Lara; Emilie Voltz; Hinrich Gronemeyer
Journal:  EMBO J       Date:  2004-07-08       Impact factor: 11.598

10.  Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis.

Authors:  Junsoo Park; Kwangsoo Kim; Eun-Ju Lee; Yun-Jee Seo; Si-Nae Lim; Kyoungsook Park; Seung Bae Rho; Seung-Hoon Lee; Je-Ho Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-17       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.