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Literature DB >> 8062148

Immunocytochemical identification of androgen receptor in mouse osteoclast-like multinucleated cells.

Y Mizuno¹, T Hosoi, S Inoue, A Ikegami, M Kaneki, Y Akedo, T Nakamura, Y Ouchi, C Chang, H Orimo.

Abstract

Expression of androgen receptor (AR) in mouse osteoclast-like multi-nucleated cells (OCs) was examined with immunocytochemical techniques. Murine OCs were obtained by co-culturing mouse osteoblastic cells and bone marrow cells. Three preparations of polyclonal anti-AR antibody which were raised in rabbit against different parts of the human AR were employed for the experiments. Specific staining for AR was demonstrated in the nuclei and the perinuclear area of mouse OCs. This is the first report demonstrating the presence of AR in osteoclast-like cells.

Entities: Gene Species

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Year: 1994 PMID： 8062148 DOI： 10.1007/bf00295958

Source DB: PubMed Journal: Calcif Tissue Int ISSN： 0171-967X Impact factor: 4.333

18 in total

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Journal: Proc Natl Acad Sci U S A Date: 1989-02 Impact factor: 11.205

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5. Characterization of human androgen receptor overexpressed in the baculovirus system.

Authors: C Chang; C Wang; H F DeLuca; T K Ross; C C Shih
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8. Characteristics of steroid hormone receptors in cultured MC3T3-E1 osteoblastic cells and effect of steroid hormones on cell proliferation.

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9. Regulation of androgen receptor by androgen and epidermal growth factor in a human prostatic cancer cell line, LNCaP.

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12 in total

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Review 2. Male osteoporosis: new trends in diagnosis and therapy.

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Journal: Proc Natl Acad Sci U S A Date: 2002-10-07 Impact factor: 11.205

Review 6. Androgens and bone.

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