| Literature DB >> 8062096 |
Abstract
The concentration of a product of lipid peroxidation (malondialdehyde) was determined in six areas of neocortex of 8 subjects with Alzheimer's disease and 8 control subjects. Malondialdehyde concentration was significantly increased by incubation with iron and ascorbate in all samples. Both basal and iron/ascorbate-stimulated malondialdehyde concentration were higher in the inferior temporal cortex of Alzheimer subjects than corresponding controls; other regions were unaffected. Basal concentrations of malondialdehyde correlated with age in both the inferior parietal lobule and the sensory/motor cortex.Entities:
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Year: 1994 PMID： 8062096 DOI： 10.1016/0006-8993(94)91670-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252