| Literature DB >> 8061825 |
L Wallén1, O Ericsson, I Wikström, U Hellgren.
Abstract
An HPLC method for analysis of the enantiomers of the antimalarial drug mefloquine is presented. A complete resolution of (-)-(11S,2'R) and (+)-(11R,2'S) erythro-mefloquine from plasma and urine was obtained on a commercial AGP column. Mefloquine enantiomers were detected by UV at 222 nm. The separation factor (alpha) at +20 degrees C was 1.50. The limit of determination (coefficient of variation 4.0%) for the enantiomeric ratio (11S,2'R)/(11R,2'S) is 15:1 at a total mefloquine concentration of 1.6 mM.Entities:
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Year: 1994 PMID： 8061825 DOI： 10.1016/0378-4347(94)00027-1
Source DB: PubMed Journal: J Chromatogr B Biomed Appl ISSN： 1572-6495