Literature DB >> 8061806

A case of hepatocellular carcinoma consisting of two solitary poorly differentiated polyclonal intrahepatic tumor nodules.

M Yamamoto1, M Matsuda, K Miura, K Nagahori, Y Matsumoto.   

Abstract

Two intrahepatic solitary tumors consisting of poorly differentiated hepatocellular carcinoma (HCC) were identified as polyclonal HCC nodules by analysis of the pattern of integration of hepatitis B viral DNA into nuclear DNA. After the removal of each nodule by partial liver resection, recurrent multiple tumors appeared within 10 months postoperatively. The findings in this case suggest that the effectiveness of reduction surgery for intrahepatic multiple tumors is limited in solitary multicentric HCC that consists of poorly differentiated HCC.

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Year:  1994        PMID： 8061806     DOI： 10.1007/bf02358377

Source DB:  PubMed          Journal:  J Gastroenterol        ISSN： 0944-1174            Impact factor:   7.527


  8 in total

1.  Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern.

Authors:  M Sakamoto; S Hirohashi; H Tsuda; Y Shimosato; M Makuuchi; Y Hosoda
Journal:  Am J Surg Pathol       Date:  1989-12       Impact factor: 6.394

2.  Hepatocellular carcinoma and hepatitis B virus infection: molecular evidence for monoclonal origin and expansion of malignantly transformed hepatocytes.

Authors:  H E Blum; W B Offensperger; E Walter; S Offensperger; A Wahl; C Zeschnigk; W Gerok
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

3.  Clonal origin of human hepatoma determined by integration of hepatitis B virus DNA.

Authors:  M Esumi; T Aritaka; M Arii; K Suzuki; K Tanikawa; H Mizuo; T Mima; T Shikata
Journal:  Cancer Res       Date:  1986-11       Impact factor: 12.701

4.  The indications for tumor mass reduction surgery and subsequent multidisciplinary treatments in stage IV hepatocellular carcinoma.

Authors:  M Yamamoto; H Iizuka; M Matsuda; K Nagahori; K Miura; J Itakura
Journal:  Surg Today       Date:  1993       Impact factor: 2.549

5.  The morphologic transition in hepatocellular carcinoma. A comparison of the individual histologic features disclosed by ultrasound-guided fine-needle biopsy with those of autopsy.

Authors:  S Sugihara; O Nakashima; M Kojiro; Y Majima; M Tanaka; K Tanikawa
Journal:  Cancer       Date:  1992-09-15       Impact factor: 6.860

6.  Different pattern of chromosomal allele loss in multiple hepatocellular carcinomas as evidence of their multifocal origin.

Authors:  H Tsuda; T Oda; M Sakamoto; S Hirohashi
Journal:  Cancer Res       Date:  1992-03-15       Impact factor: 12.701

7.  Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma.

Authors:  T Oda; H Tsuda; A Scarpa; M Sakamoto; S Hirohashi
Journal:  Cancer Res       Date:  1992-07-01       Impact factor: 12.701

Review 8.  The general rules for the clinical and pathological study of primary liver cancer. Liver Cancer Study Group of Japan.

Authors: 
Journal:  Jpn J Surg       Date:  1989-01
  8 in total

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