| Literature DB >> 8060307 |
G M Wilkins1, A W Segal, D S Leake.
Abstract
NADPH oxidase has been reported to be involved in low density lipoprotein (LDL) oxidation by monocytes. We have investigated the ability of monocyte-derived macrophages from four chronic granulomatous disease patients, which lack NADPH oxidase, to oxidise LDL. All the cells oxidised LDL to significantly increase its uptake by mouse macrophages. We conclude therefore that NADPH oxidase is not essential for LDL oxidation by macrophages.Entities:
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Year: 1994 PMID： 8060307 DOI： 10.1006/bbrc.1994.2072
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575