Dietary fatty acids and breast cancer invasion and metastasis.

This review presents the evidence for the hypothesis that dietary linoleic acid and its metabolic derivative arachidonic acid enhance the metastatic process in breast cancer. Key biochemical events are eicosanoid biosynthesis and protein kinase C activation, both of which are involved in tumor cell invasion and angiogenesis. It is concluded that the utilization of appropriate dietary interventions and pharmacological inhibitors offers a promising approach to suppress metastasis.