Literature DB >> 8058471

Identification of an ATP-sensitive K+ channel in spiny neurons of rat caudate nucleus.

C Schwanstecher1, U Panten.   

Abstract

On the somata of GABAergic spiny neurons in the caudate nucleus of the rat an ATP-sensitive K+ channel (KATP-channel) was identified. The KATP-currents in cell-attached patches were activated both by energy-depleting conditions (200 microM cyanide) and by diazoxide (300 microM) and were reversibly blocked by tolbutamide (EC50 = 5 microM). In inside-out patch membranes both ATP (1 mM) and its non-hydrolyzable analog AMP-PNP (adenylylimidodiphosphate; EC50 = 27 microM) reversibly inhibited channel activity. These results demonstrate that the KATP-channel in spiny neurons displays properties characteristic of the KATP-channel in hippocampal, neocortical and nigral neurons and in pancreatic beta-cells.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8058471     DOI： 10.1007/bf00585961

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  7 in total

1.  Patch-clamping cells in sliced tissue preparations.

Authors:  F A Edwards; A Konnerth
Journal:  Methods Enzymol       Date:  1992       Impact factor: 1.600

2.  Identification of an ATP-sensitive K+ channel in rat cultured cortical neurons.

Authors:  T Ohno-Shosaku; C Yamamoto
Journal:  Pflugers Arch       Date:  1992-12       Impact factor: 3.657

Review 3.  The pharmacology of ATP-sensitive potassium channels.

Authors:  G Edwards; A H Weston
Journal:  Annu Rev Pharmacol Toxicol       Date:  1993       Impact factor: 13.820

4.  Interaction of tolbutamide and cytosolic nucleotides in controlling the ATP-sensitive K+ channel in mouse beta-cells.

Authors:  C Schwanstecher; C Dickel; U Panten
Journal:  Br J Pharmacol       Date:  1994-01       Impact factor: 8.739

5.  ATP-sensitive K+ channel activators suppress the GABAergic inhibitory transmission by acting on both presynaptic and postsynaptic sites in rat cultured hippocampal neurons.

Authors:  T Ohno-Shosaku; S Sawada; C Yamamoto
Journal:  Neurosci Lett       Date:  1993-09-03       Impact factor: 3.046

6.  Tolbutamide- and diazoxide-sensitive K+ channel in neurons of substantia nigra pars reticulata.

Authors:  C Schwanstecher; U Panten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-07       Impact factor: 3.000

7.  Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels.

Authors:  S Amoroso; H Schmid-Antomarchi; M Fosset; M Lazdunski
Journal:  Science       Date:  1990-02-16       Impact factor: 47.728
  7 in total
  7 in total

1.  ATP-sensitive K+ channels are functional in expiratory neurones of normoxic cats.

Authors:  O Pierrefiche; A M Bischoff; D W Richter
Journal:  J Physiol       Date:  1996-07-15       Impact factor: 5.182

2.  KATP channel formation by the sulphonylurea receptors SUR1 with Kir6.2 subunits in rat dorsal vagal neurons in situ.

Authors:  A Karschin; J Brockhaus; K Ballanyi
Journal:  J Physiol       Date:  1998-06-01       Impact factor: 5.182

3.  Subsecond regulation of striatal dopamine release by pre-synaptic KATP channels.

Authors:  Jyoti C Patel; Paul Witkovsky; William A Coetzee; Margaret E Rice
Journal:  J Neurochem       Date:  2011-08-04       Impact factor: 5.372

4.  KATP channel mediation of anoxia-induced outward current in rat dorsal vagal neurons in vitro.

Authors:  S Trapp; K Ballanyi
Journal:  J Physiol       Date:  1995-08-15       Impact factor: 5.182

Review 5.  Classification of H₂O₂as a neuromodulator that regulates striatal dopamine release on a subsecond time scale.

Authors:  Jyoti C Patel; Margaret E Rice
Journal:  ACS Chem Neurosci       Date:  2012-11-08       Impact factor: 4.418

6.  Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones.

Authors:  K Lee; A K Dixon; T C Freeman; P J Richardson
Journal:  J Physiol       Date:  1998-07-15       Impact factor: 5.182

7.  Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus.

Authors:  C Zawar; T D Plant; C Schirra; A Konnerth; B Neumcke
Journal:  J Physiol       Date:  1999-01-15       Impact factor: 5.182
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.