Literature DB >> 8057832

The mechanism of transcription termination by RNA polymerase I.

R H Reeder1, W Lang.   

Abstract

Eukaryotic ribosomal gene transcription units are bordered at their 3' ends by short DNA sequences which specify site-specific termination by RNA polymerase I (polI). PolI terminators from yeast through to mammals appear to follow similar rules: they contain a site for a sequence-specific DNA-binding protein; they function only in one orientation; 3' ends are formed upstream of the binding site; and 5' flanking sequences influence the position and efficiency of 3' end formation. Recent progress in understanding the mechanism of RNA chain elongation by other polymerases suggests a model for polI termination in which termination is seen as one of the several outcomes possible when a polymerase encounters a pause site.

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Year:  1994        PMID： 8057832     DOI： 10.1111/j.1365-2958.1994.tb00989.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  14 in total

1.  Novel transcript truncating function of Rap1p revealed by synthetic codon-optimized Ty1 retrotransposon.

Authors:  Robert M Yarrington; Sarah M Richardson; Cheng Ran Lisa Huang; Jef D Boeke
Journal:  Genetics       Date:  2011-11-30       Impact factor: 4.562

2.  Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.

Authors:  P Jansa; S W Mason; U Hoffmann-Rohrer; I Grummt
Journal:  EMBO J       Date:  1998-05-15       Impact factor: 11.598

3.  Characterization of a transcription terminator of the procyclin PARP A unit of Trypanosoma brucei.

Authors:  M Berberof; A Pays; S Lips; P Tebabi; E Pays
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

4.  Oligomerization of the transcription termination factor TTF-I: implications for the structural organization of ribosomal transcription units.

Authors:  E E Sander; I Grummt
Journal:  Nucleic Acids Res       Date:  1997-03-15       Impact factor: 16.971

5.  Molecular cloning and analysis of Schizosaccharomyces pombe Reb1p: sequence-specific recognition of two sites in the far upstream rDNA intergenic spacer.

Authors:  A Zhao; A Guo; Z Liu; L Pape
Journal:  Nucleic Acids Res       Date:  1997-02-15       Impact factor: 16.971

6.  Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe.

Authors:  Rahul Jaiswal; Malay Choudhury; Shamsu Zaman; Samarendra Singh; Vishaka Santosh; Deepak Bastia; Carlos R Escalante
Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-28       Impact factor: 11.205

7.  The amino-terminal domain of the transcription termination factor TTF-I causes protein oligomerization and inhibition of DNA binding.

Authors:  E E Sander; S W Mason; C Munz; I Grummt
Journal:  Nucleic Acids Res       Date:  1996-10-01       Impact factor: 16.971

8.  Transcription termination of RNA polymerase I due to a T-rich element interacting with Reb1p.

Authors:  W H Lang; R H Reeder
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-10       Impact factor: 11.205

9.  Transcriptional terminators of RNA polymerase II are associated with yeast replication origins.

Authors:  S Chen; R Reger; C Miller; L E Hyman
Journal:  Nucleic Acids Res       Date:  1996-08-01       Impact factor: 16.971

10.  Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I.

Authors:  R Evers; I Grummt
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205
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