Literature DB >> 8057435

The p15gag and p12gag regions are both necessary for the pathogenicity of the murine AIDS virus.

Y Kubo1, K Kakimi, K Higo, L Wang, H Kobayashi, K Kuribayashi, T Masuda, T Hirama, A Ishimoto.   

Abstract

The defective murine AIDS (MAIDS) virus has unique sequences in its p15gag and p12gag regions. To clarify whether these sequences are responsible for the development of MAIDS, we constructed recombinant viruses by replacing various regions of the gag gene of the nonpathogenic replication-competent LP-BM5 ecotropic virus with those of the MAIDS virus. Recombinants containing both unique sequences of the MAIDS virus were replication defective and induced MAIDS. However, a recombinant containing either the p15gag or p12gag region of the MAIDS virus was also replication defective but nonpathogenic in mice. A recombinant virus containing only the p30gag region of the MAIDS virus was replication competent and nonpathogenic. These results indicate that the p15gag and p12gag regions of the MAIDS virus do not function like those of replication-competent viruses and that both of the unique sequences in the p15gag and p12gag regions are required to develop MAIDS.

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Year:  1994        PMID： 8057435      PMCID： PMC236953     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

Review 1.  Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS.

Authors:  H C Morse; S K Chattopadhyay; M Makino; T N Fredrickson; A W Hügin; J W Hartley
Journal:  AIDS       Date:  1992-07       Impact factor: 4.177

2.  Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice.

Authors:  S K Chattopadhyay; D N Sengupta; T N Fredrickson; H C Morse; J W Hartley
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

3.  Experiment and discussion on leukaemogenesis by cell-free extracts of radiation-induced leukaemia in mice.

Authors:  R LATARJET; J F DUPLAN
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1962-08

Review 4.  Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis.

Authors:  P Jolicoeur
Journal:  FASEB J       Date:  1991-07       Impact factor: 5.191

5.  Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome.

Authors:  S K Chattopadhyay; H C Morse; M Makino; S K Ruscetti; J W Hartley
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

6.  The majority of cells infected with the defective murine AIDS virus belong to the B-cell lineage.

Authors:  M Huang; C Simard; D G Kay; P Jolicoeur
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

7.  Presence of transplantable T-lymphoid cells in C57BL/6 mice infected with murine AIDS virus.

Authors:  Y Kubo; Y Nakagawa; K Kakimi; H Matsui; M Iwashiro; K Kuribayashi; T Masuda; H Hiai; T Hirama; S Yanagawa
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

8.  A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice.

Authors:  A W Hügin; M S Vacchio; H C Morse
Journal:  Science       Date:  1991-04-19       Impact factor: 47.728

9.  Mouse mammary tumor virus with rearranged long terminal repeats causes murine lymphomas.

Authors:  S Yanagawa; K Kakimi; H Tanaka; A Murakami; Y Nakagawa; Y Kubo; Y Yamada; H Hiai; K Kuribayashi; T Masuda
Journal:  J Virol       Date:  1993-01       Impact factor: 5.103

10.  CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy.

Authors:  G Muralidhar; S Koch; M Haas; S L Swain
Journal:  J Exp Med       Date:  1992-06-01       Impact factor: 14.307
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  8 in total

1.  Bacterial lipopolysaccharide enhances cardiac dysfunction but not retroviral replication in murine AIDS: roles of macrophage infiltration and toll-like receptor 4 expression.

Authors:  Alysia A Chaves; Reshma S Baliga; Michael J Mihm; Brandon L Schanbacher; Anupam Basuray; Cynthia Liu; Angela C Cook; Leona W Ayers; John Anthony Bauer
Journal:  Am J Pathol       Date:  2006-03       Impact factor: 4.307

2.  Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas.

Authors:  B C Cho; J D Shaughnessy; D A Largaespada; H G Bedigian; A M Buchberg; N A Jenkins; N G Copeland
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

Review 3.  Cells and cytokines in the pathogenesis of MAIDS, a retrovirus-induced immunodeficiency syndrome of mice.

Authors:  H C Morse; N Giese; R Morawetz; Y Tang; R Gazzinelli; W K Kim; S Chattopadhyay; J W Hartley
Journal:  Springer Semin Immunopathol       Date:  1995

4.  Role of a cytotoxic-T-lymphocyte epitope-defined, alternative gag open reading frame in the pathogenesis of a murine retrovirus-induced immunodeficiency syndrome.

Authors:  Arti Gaur; William R Green
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

5.  The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl.

Authors:  P Dupraz; N Rebai; S J Klein; N Beaulieu; P Jolicoeur
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

6.  Alpha/beta interferons increase host resistance to murine AIDS.

Authors:  J K Heng; P Price; C M Lai; M W Beilharz
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

7.  Possible origin of murine AIDS (MAIDS) virus: conversion of an endogenous retroviral p12gag sequence to a MAIDS-inducing sequence by frameshift mutations.

Authors:  Y Kubo; K Kakimi; K Higo; H Kobayashi; T Ono; Y Iwama; K Kuribayashi; H Hiai; A Adachi; A Ishimoto
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

8.  Evidence that the murine AIDS defective virus does not encode a superantigen.

Authors:  L Doyon; C Simard; R P Sékaly; P Jolicoeur
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103
  8 in total

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