Literature DB >> 8057293

Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.

S Niwas1, P Chand, V P Pathak, J A Montgomery.   

Abstract

The synthesis and evaluation as inhibitors of purine nucleoside phosphorylase of six 9-deazahypoxanthines (2a-f) are reported. In contrast to reports in the literature of other hypoxanthine-guanine analog pairs, these inhibitors (2a-f) are equipotent with the corresponding 9-deazaguanines.

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Year:  1994        PMID: 8057293     DOI: 10.1021/jm00041a027

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  2 in total

1.  Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines.

Authors:  Kartik W Temburnikar; Christina R Ross; Gerald M Wilson; Jan Balzarini; Brian M Cawrse; Katherine L Seley-Radtke
Journal:  Bioorg Med Chem       Date:  2015-06-16       Impact factor: 3.641

2.  3-(4-Fluoro-phen-yl)-2-(4-methoxy-phen-oxy)-4-oxo-5-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carbonitrile.

Authors:  Guo-Ping Zeng; Shi-Rong Yan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-08-06
  2 in total

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