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Literature DB >> 805648

The use of trimethoprim-sulfamethoxazole in gonococcal infections.

Abstract

In a multicentre trial of trimethoprim-sulfamethoxazole (TMP-SMX) for the treatment of uncomplicated gonococcal urethritis, optimal results were achieved with a regimen of six tablets once daily for 3 days. Treatment failure was found to be related significantly to the relative resistance to SMX of the pretreatment isolate. Further, the difference between therapeutic results from various geographic areas could be correlated with the relative sensitivity of pretreatment isolates to both SMX and TMP for that area. In view of these observations the role of TMP-SMX in the treatment of gonococcal disease is discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1975 PMID： 805648 PMCID： PMC1956443

Source DB: PubMed Journal: Can Med Assoc J ISSN： 0008-4409 Impact factor: 8.262

13 in total

1. Trimethoprim-sulphamethoxazole in gonorrhoea.

Authors: S Ullman; A M Niordson; H Zachariae
Journal: Acta Derm Venereol Date: 1971 Impact factor: 4.437

2. Sulphamethoxazole combined with 2-4-diamino-pyrimidines in the treatment of gonorrhoea.

Authors: D J Wright; A S Grimble
Journal: Br J Vener Dis Date: 1970-02

3. Gonorrhea. Trimethoprim-sulfamethoxazole in the treatment of gonococcal urethritis: clinical and laboratory correlates.

Authors: T W Austin; G F Brooks; M Bethel; F L Roberts; M Turck; K K Holmes
Journal: J Infect Dis Date: 1973-11 Impact factor: 5.226

Review 3. Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy.

Authors: G P Wormser; G T Keusch; R C Heel
Journal: Drugs Date: 1982-12 Impact factor: 9.546

3 in total

The use of trimethoprim-sulfamethoxazole in gonococcal infections.

1. Trimethoprim-sulphamethoxazole in gonorrhoea.

2. Sulphamethoxazole combined with 2-4-diamino-pyrimidines in the treatment of gonorrhoea.

3. Gonorrhea. Trimethoprim-sulfamethoxazole in the treatment of gonococcal urethritis: clinical and laboratory correlates.

4. Treatment of gonorrhoea with trimethoprim-sulphamethoxazole and with rifampicin.

5. Therapeutic trial of trimethoprim as a potentiator of sulphonamides in gonorrhoea.

6. Various regimens of trimethoprim-sulfamethoxazole used in the treatment of gonorrhea.

7. Gonococcal pharyngeal infections. Report of 110 cases.

8. Gonorrhea in women: treatment with sulfamethoxazole and trimethoprim.

9. Treatment of gonorrhoea with trimethoprim-sulphamethoxazole in Uganda.

10. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.

1. Synergistic interaction of trimethoprim and sulfamethoxazole on Paracoccidioides brasiliensis.

2. Penetration of trimethoprim and sulfamethoxazole into skin blister fluid.

Review 3. Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy.