Literature DB >> 8056194

Simple tandem repeat DNA polymorphism in the human glycogen synthase gene is associated with NIDDM in Japanese subjects.

H Kuroyama1, T Sanke, S Ohagi, M Furuta, H Furuta, K Nanjo.   

Abstract

We investigated the possible association between alleles of a simple tandem repeat DNA polymorphism in the human glycogen synthase gene and non-obese non-insulin-dependent diabetes (NIDDM) in Japanese subjects. Nine alleles (-4G, -3G, -2G, -1G, 0G, 1G, 2G, 3G, and 4G) were identified in the study group of 164 patients with NIDDM and 115 non-diabetic subjects. The overall frequency distribution of the glycogen synthase gene alleles was significantly different between the two groups (p = 0.0316). The 2G allele was found more frequently in patients with NIDDM than in non-diabetic subjects (17.7% vs 8.7%, p = 0.0016). These results suggest that the 2G allele could be a genetic marker of NIDDM in Japanese subjects.

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Year:  1994        PMID： 8056194     DOI： 10.1007/s001250050144

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  10 in total

1.  Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus.

Authors:  T Kadowaki; H Kadowaki; Y Yazaki
Journal:  N Engl J Med       Date:  1993-05-27       Impact factor: 91.245

2.  Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus.

Authors:  H Zouali; G Velho; P Froguel
Journal:  N Engl J Med       Date:  1993-05-27       Impact factor: 91.245

3.  Identification of a simple tandem repeat DNA polymorphism in the human glycogen synthase gene and linkage to five markers on chromosome 19q.

Authors:  N Vionnet; G I Bell
Journal:  Diabetes       Date:  1993-06       Impact factor: 9.461

4.  Impaired activation of glycogen synthase in people at increased risk for developing NIDDM.

Authors:  C Schalin-Jäntti; M Härkonen; L C Groop
Journal:  Diabetes       Date:  1992-05       Impact factor: 9.461

Review 5.  Use of DNA polymorphisms for genetic analysis of non-insulin dependent diabetes mellitus.

Authors:  M A Permutt
Journal:  Baillieres Clin Endocrinol Metab       Date:  1991-09

6.  Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus.

Authors:  A Vaag; J E Henriksen; H Beck-Nielsen
Journal:  J Clin Invest       Date:  1992-03       Impact factor: 14.808

7.  Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients.

Authors:  H Vestergaard; C Bjørbaek; P H Andersen; J F Bak; O Pedersen
Journal:  Diabetes       Date:  1991-12       Impact factor: 9.461

8.  Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus.

Authors:  A W Thorburn; B Gumbiner; F Bulacan; G Brechtel; R R Henry
Journal:  J Clin Invest       Date:  1991-02       Impact factor: 14.808

9.  Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus.

Authors:  L C Groop; M Kankuri; C Schalin-Jäntti; A Ekstrand; P Nikula-Ijäs; E Widén; E Kuismanen; J Eriksson; A Franssila-Kallunki; C Saloranta
Journal:  N Engl J Med       Date:  1993-01-07       Impact factor: 91.245

10.  Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus.

Authors:  H Vestergaard; S Lund; F S Larsen; O J Bjerrum; O Pedersen
Journal:  J Clin Invest       Date:  1993-06       Impact factor: 14.808
  10 in total
  5 in total

1.  Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes.

Authors:  S J Hasstedt; M Hoffman; M F Leppert; S C Elbein
Journal:  Am J Hum Genet       Date:  1997-09       Impact factor: 11.025

2.  The glycogen synthase gene in NIDDM and hypertension.

Authors:  Y Hamada; H Ikegami; Y Fujioka; E Yamato; K Takekawa; T Fujisawa; Y Nakagawa; H Ueda; J Fu; G Q Shen
Journal:  Diabetologia       Date:  1995-10       Impact factor: 10.122

3.  Association of the glycogen synthase locus on 19q13 with NIDDM in Pima Indians.

Authors:  M Majer; D M Mott; H Mochizuki; J C Rowles; O Pedersen; W C Knowler; C Bogardus; M Prochazka
Journal:  Diabetologia       Date:  1996-03       Impact factor: 10.122

4.  Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms.

Authors:  R R Henry; T P Ciaraldi; L Abrams-Carter; S Mudaliar; K S Park; S E Nikoulina
Journal:  J Clin Invest       Date:  1996-09-01       Impact factor: 14.808

5.  New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.

Authors:  J Rissanen; J Pihlajamäki; S Heikkinen; P Kekäläinen; L Mykkänen; J Kuusisto; A Kolle; M Laakso
Journal:  Diabetologia       Date:  1997-11       Impact factor: 10.122
  5 in total

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