Literature DB >> 8056052

A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice.

A Baron1, K Hafen, H von Boehmer.   

Abstract

The specificity of the alpha beta T cell receptor for class I or class II major histocompatibility complex (MHC) molecules determines whether a mature T cell will be of the CD4-CD8+ or CD4+CD8- phenotype, respectively. We show here that a human CD4 transgene can rescue a significant fraction of CD4-CD8+ T cells in beta 2-microglobulin-deficient mice. Cells with this phenotype could be induced to become potent killers of targets expressing allogeneic MHC antigens, indicating that lineage commitment can precede the rescue of developing cells by the T cell receptor for antigen and the CD4 coreceptor.

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Year:  1994        PMID： 8056052     DOI： 10.1002/eji.1830240834

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  10 in total

Review 1.  Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.

Authors:  Alfred Singer; Stanley Adoro; Jung-Hyun Park
Journal:  Nat Rev Immunol       Date:  2008-10       Impact factor: 53.106

2.  Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.

Authors:  Stanley Adoro; Batu Erman; Sophia D Sarafova; François Van Laethem; Jung-Hyun Park; Lionel Feigenbaum; Alfred Singer
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

3.  Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway.

Authors:  B Lucas; F Vasseur; C Penit
Journal:  J Exp Med       Date:  1995-05-01       Impact factor: 14.307

4.  Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

Authors:  K Lundberg; W Heath; F Köntgen; F R Carbone; K Shortman
Journal:  J Exp Med       Date:  1995-05-01       Impact factor: 14.307

5.  Dynamic repositioning of CD4 and CD8 genes during T cell development.

Authors:  Stephanie Delaire; Yina Hsing Huang; Shaio Wei Chan; Ellen A Robey
Journal:  J Exp Med       Date:  2004-12-06       Impact factor: 14.307

6.  Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.

Authors:  J A Punt; H Suzuki; L G Granger; S O Sharrow; A Singer
Journal:  J Exp Med       Date:  1996-12-01       Impact factor: 14.307

Review 7.  CD4/CD8 lineage commitment: back to instruction?

Authors:  H von Boehmer
Journal:  J Exp Med       Date:  1996-03-01       Impact factor: 14.307

8.  Visualization of CD4/CD8 T cell commitment.

Authors:  S Chan; M Correia-Neves; A Dierich; C Benoist; D Mathis
Journal:  J Exp Med       Date:  1998-12-21       Impact factor: 14.307

9.  Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

Authors:  P Kisielow; A Miazek
Journal:  J Exp Med       Date:  1995-06-01       Impact factor: 14.307

10.  The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

Authors:  A Itano; P Salmon; D Kioussis; M Tolaini; P Corbella; E Robey
Journal:  J Exp Med       Date:  1996-03-01       Impact factor: 14.307
  10 in total

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