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Literature DB >> 8055616

Propofol inhibits phagocytosis and killing of Staphylococcus aureus and Escherichia coli by polymorphonuclear leukocytes in vitro.

Abstract

Polymorphonuclear leukocytes (PMNL) are important components of the immunological defence system which protects the human organism from invading bacteria. Using a fluorescence microscopic method, we examined the influence of propofol and its solvent intralipid on phagocytosis and killing of Staphylococcus aureus and Escherichia coli by PMNL in vitro. Propofol inhibited (P < or = 0.001) phagocytosis of Staphylococcus aureus as well as Escherichia coli. Killing of Staphylococcus aureus (P < or = 0.001) and of Escherichia coli (P < or = 0.01) was suppressed. Intralipid, by itself, impaired phagocytosis of Escherichia coli (P < or = 0.05). Apart from that, intralipid produced no relevant effects. Additional clinical studies regarding the influence of propofol on PMNL function are recommended.

Entities: Chemical Species

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Year: 1994 PMID： 8055616 DOI： 10.1007/BF03009871

Source DB: PubMed Journal: Can J Anaesth ISSN： 0832-610X Impact factor: 5.063

6 in total

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6 in total

7 in total

Review 1. Anesthetics, immune cells, and immune responses.

Authors: Shin Kurosawa; Masato Kato
Journal: J Anesth Date: 2008-08-07 Impact factor: 2.078

2. Propofol inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation.

Authors: Hiroe Shiratsuchi; Yasser Kouatli; Guang Xiang Yu; Harold M Marsh; Marc D Basson
Journal: Am J Physiol Cell Physiol Date: 2009-04-08 Impact factor: 4.249

7. Protocol for a multicentre, prospective cohort study of practice patterns and clinical outcomes associated with emergency department sedation for mechanically ventilated patients: the ED-SED Study.

Authors: Brian M Fuller; Nicholas M Mohr; Brian W Roberts; Christopher R Carpenter; Marin H Kollef; Michael S Avidan
Journal: BMJ Open Date: 2018-10-21 Impact factor: 2.692