Literature DB >> 8055181

Functions of human papillomavirus E6 and E7 oncoproteins.

A J Farthing1, K H Vousden.   

Abstract

The identification of certain human papillomaviruses as human tumour viruses has been paralleled by our understanding of how the viral oncoproteins function. The virally encoded E6 and E7 proteins act, in part, to abrogate the activities of the tumour suppressor proteins p53 and pRB. The interaction between these viral proteins and regulators of cell growth offers targets for future therapeutic developments.

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Year:  1994        PMID： 8055181     DOI： 10.1016/0966-842x(94)90667-x

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  10 in total

1.  Single amino acid substitutions on the surface of Escherichia coli maltose-binding protein can have a profound impact on the solubility of fusion proteins.

Authors:  J D Fox; R B Kapust; D S Waugh
Journal:  Protein Sci       Date:  2001-03       Impact factor: 6.725

2.  Mutation of Tp53 contributes to the malignant phenotype of Abelson virus-transformed lymphoid cells.

Authors:  K C Thome; A Radfar; N Rosenberg
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

3.  Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication.

Authors:  Q M Chen; J C Bartholomew; J Campisi; M Acosta; J D Reagan; B N Ames
Journal:  Biochem J       Date:  1998-05-15       Impact factor: 3.857

4.  MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin γ2 expression in oral dysplasia and squamous cell carcinoma.

Authors:  Martin Degen; Easwar Natarajan; Patricia Barron; Hans R Widlund; James G Rheinwald
Journal:  Am J Pathol       Date:  2012-04-28       Impact factor: 4.307

5.  The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.

Authors:  Latha Shivakumar; John Minna; Toshiyuki Sakamaki; Richard Pestell; Michael A White
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

6.  Immunization and immunotherapy for cancers involving infection by a human papillomavirus in a mouse model.

Authors:  Jin Li; Ying Sun; Alan Garen
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-21       Impact factor: 11.205

7.  Epigenetic changes in the CDKN2A locus are associated with differential expression of P16INK4A and P14ARF in HPV-positive oropharyngeal squamous cell carcinoma.

Authors:  Nicolas F Schlecht; Miriam Ben-Dayan; Nicole Anayannis; Roberto A Lleras; Carlos Thomas; Yanhua Wang; Richard V Smith; Robert D Burk; Thomas M Harris; Geoffrey Childs; Thomas J Ow; Michael B Prystowsky; Thomas J Belbin
Journal:  Cancer Med       Date:  2015-01-26       Impact factor: 4.452

8.  The distribution and common amino acid polymorphisms of human papillomavirus (HPV)-31 variants in 2700 women from Northern China.

Authors:  Mengfei Liu; Zhonghu He; Longfu Xi; Jingjing Li; Fangfang Liu; Ying Liu; Yaqi Pan; Tao Ning; Chuanhai Guo; Ruiping Xu; Lixin Zhang; Hong Cai; Yang Ke
Journal:  PLoS One       Date:  2014-06-05       Impact factor: 3.240

9.  Taxifolin and Lucidin as Potential E6 Protein Inhibitors: p53 Function Re-Establishment and Apoptosis Induction in Cervical Cancer Cells.

Authors:  Diana Gomes; Shivani Yaduvanshi; Samuel Silvestre; Ana Paula Duarte; Adriana O Santos; Christiane P Soares; Veerendra Kumar; Luís Passarinha; Ângela Sousa
Journal:  Cancers (Basel)       Date:  2022-06-08       Impact factor: 6.575

10.  A Decade of Global mRNA and miRNA Profiling of HPV-Positive Cell Lines and Clinical Specimens.

Authors:  Bogumil Kaczkowski; Marya Morevati; Maria Rossing; Finn Cilius; Bodil Norrild
Journal:  Open Virol J       Date:  2012-12-28
  10 in total

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