Literature DB >> 8054262

Stimulation of phospholipase A2 activity in mitochondria by magnesium and polyamines.

N E Saris1.   

Abstract

Endogenous phospholipase A2 activity in hypotonically swollen, non-respiring rat liver mitochondria was found to be stimulated by 1-10 mM magnesium and by 0.5-1.2 mM of the polyamines spermine and spermidine in the absence of added calcium. This was interpreted as being due to effects of these cations on the physicochemical properties of membrane phospholipids. The activity in the presence of 0.2 mM calcium was inhibited by 0.2 mM strontium. The calcium-stimulated activities were stimulated more than twofold in hypotonically (50 mOsm/litre) swollen mitochondria in comparison with non-swollen mitochondria.

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Year:  1994        PMID： 8054262

Source DB:  PubMed          Journal:  Magnes Res        ISSN： 0953-1424            Impact factor:   1.115


  3 in total

Review 1.  Mitochondrial Cyclosporine A-Independent Palmitate/Ca2+-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity.

Authors:  Galina D Mironova; Evgeny V Pavlov
Journal:  Cells       Date:  2021-01-11       Impact factor: 6.600

2.  The Short-Term Opening of Cyclosporin A-Independent Palmitate/Sr2+-Induced Pore Can Underlie Ion Efflux in the Oscillatory Mode of Functioning of Rat Liver Mitochondria.

Authors:  Natalia V Belosludtseva; Lyubov L Pavlik; Konstantin N Belosludtsev; Nils-Erik L Saris; Maria I Shigaeva; Galina D Mironova
Journal:  Membranes (Basel)       Date:  2022-06-28

3.  Mitochondrial Ca2+ cycle mediated by the palmitate-activated cyclosporin A-insensitive pore.

Authors:  Galina D Mironova; Konstantin N Belosludtsev; Natalia V Belosludtseva; Elena N Gritsenko; Boris I Khodorov; Nils-Erik L Saris
Journal:  J Bioenerg Biomembr       Date:  2007-05-25       Impact factor: 3.853
  3 in total

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