OBJECTIVE: To examine the relationship between serum levels of insulin-like growth factor 1 (IGF-1) and osteoarthritis (OA) of the knee. METHODS: Serum IGF-1 levels were compared in 162 male and 101 female subjects age > or = 20 stratified by presence of radiographic changes of OA of the knee. RESULTS: Mean serum IGF-1 levels were significantly lower in subjects with knee OA; however, after adjustment for age-related changes in IGF-1 levels, these differences were no longer significant. CONCLUSION: These data fail to support the hypothesis that serum IGF-1 levels are reduced in subjects with OA of the knee independent of the known age-related changes in these levels.
OBJECTIVE: To examine the relationship between serum levels of insulin-like growth factor 1 (IGF-1) and osteoarthritis (OA) of the knee. METHODS: Serum IGF-1 levels were compared in 162 male and 101 female subjects age > or = 20 stratified by presence of radiographic changes of OA of the knee. RESULTS: Mean serum IGF-1 levels were significantly lower in subjects with knee OA; however, after adjustment for age-related changes in IGF-1 levels, these differences were no longer significant. CONCLUSION: These data fail to support the hypothesis that serum IGF-1 levels are reduced in subjects with OA of the knee independent of the known age-related changes in these levels.
Authors: G Zhai; F Rivadeneira; J J Houwing-Duistermaat; I Meulenbelt; C Bijkerk; A Hofman; J B J van Meurs; A G Uitterlinden; H A P Pols; P E Slagboom; C M van Duijn Journal: Ann Rheum Dis Date: 2004-05 Impact factor: 19.103
Authors: April Hartley; Eleanor Sanderson; Lavinia Paternoster; Alexander Teumer; Robert C Kaplan; Jon H Tobias; Celia L Gregson Journal: Rheumatology (Oxford) Date: 2021-04-06 Impact factor: 7.580