OBJECTIVE: To investigate whether the findings of magnetic resonance imaging (MRI) reflect rheumatoid synovitis. METHODS: Dynamic imaging enhanced with gadolinium-diethylenetriamine pentaacetic acid was performed on 10 affected knees of 9 patients with rheumatoid arthritis. Changes in signal intensity were correlated with pathologic findings in synovial biopsy specimens obtained during total knee arthroplasty. RESULTS: Enhancement was greater in regions with a higher degree of fibrin exudation, cellular infiltration, villous hypertrophy, vascular proliferation, and granulation formation. CONCLUSION: Dynamic MRI can be used for assessing local disease activity in rheumatoid synovium.
OBJECTIVE: To investigate whether the findings of magnetic resonance imaging (MRI) reflect rheumatoid synovitis. METHODS: Dynamic imaging enhanced with gadolinium-diethylenetriamine pentaacetic acid was performed on 10 affected knees of 9 patients with rheumatoid arthritis. Changes in signal intensity were correlated with pathologic findings in synovial biopsy specimens obtained during total knee arthroplasty. RESULTS: Enhancement was greater in regions with a higher degree of fibrin exudation, cellular infiltration, villous hypertrophy, vascular proliferation, and granulation formation. CONCLUSION: Dynamic MRI can be used for assessing local disease activity in rheumatoid synovium.
Authors: Jan Fritz; Eva K Galeczko; Nina Schwenzer; Michael Fenchel; Claus D Claussen; John A Carrino; Marius S Horger Journal: Eur Radiol Date: 2009-04-25 Impact factor: 5.315
Authors: A Alonso-Ruiz; F Pérez-Ruiz; M Calabozo; F Saez; J Ignacio Pijoan; E Ruiz-Lucea; I Aretxabala; G Ríos Journal: Clin Rheumatol Date: 1998 Impact factor: 2.980