Literature DB >> 8053661

Decreased dopamine transporters with age in health human subjects.

N D Volkow1, J S Fowler, G J Wang, J Logan, D Schlyer, R MacGregor, R Hitzemann, A P Wolf.   

Abstract

The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21-63 years) using positron emission tomography and [11C]cocaine. The ratio of the distribution volume for [11C]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). This results document an age-related decline in dopamine transporters in healthy individuals.

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Year:  1994        PMID： 8053661     DOI： 10.1002/ana.410360218

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  33 in total

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2.  Prescription use disorders in older adults.

Authors:  Raj K Kalapatapu; Maria A Sullivan
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Review 3.  Neurobehavioral evidence for changes in dopamine system activity during adolescence.

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4.  Longitudinal changes of dopamine transporters in heroin users during abstinence.

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Journal:  Psychopharmacology (Berl)       Date:  2015-06-23       Impact factor: 4.530

5.  Binding of 3H-WIN-35,428 and 125I-RTI-121 to human platelet membranes.

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Journal:  Neurochem Res       Date:  2006-05-03       Impact factor: 3.996

6.  Dopamine transporter gene susceptibility to methylation is associated with impulsivity in nonhuman primates.

Authors:  Abigail Z Rajala; Ismail Zaitoun; Jeffrey B Henriques; Alexander K Converse; Dhanabalan Murali; Miles L Epstein; Luis C Populin
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7.  Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse.

Authors:  Ulrika H Julku; Anne E Panhelainen; Saija E Tiilikainen; Reinis Svarcbahs; Anne E Tammimäki; T Petteri Piepponen; Mari H Savolainen; Timo T Myöhänen
Journal:  Mol Neurobiol       Date:  2016-12-13       Impact factor: 5.590

8.  Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls.

Authors:  Walter Koch; Marcus Unterrainer; Guoming Xiong; Peter Bartenstein; Markus Diemling; Andrea Varrone; John C Dickson; Livia Tossici-Bolt; Terez Sera; Susanne Asenbaum; Jan Booij; Ozlem L Kapucu; Andreas Kluge; Morten Ziebell; Jacques Darcourt; Flavio Nobili; Marco Pagani; Swen Hesse; Thierry Vander Borght; Koen Van Laere; Klaus Tatsch; Christian la Fougère
Journal:  Eur J Nucl Med Mol Imaging       Date:  2014-05-08       Impact factor: 9.236

Review 9.  Comparing the effects of food restriction and overeating on brain reward systems.

Authors:  Nicole M Avena; Susan Murray; Mark S Gold
Journal:  Exp Gerontol       Date:  2013-03-25       Impact factor: 4.032

Review 10.  Vulnerable neural systems and the borderland of brain aging and neurodegeneration.

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Journal:  Neuron       Date:  2013-01-23       Impact factor: 17.173
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