Literature DB >> 805187

Bacteriophages and endotoxin in licensed live-virus vaccines.

E E Moody, M D Trousdale, J H Jorgensen, A Shelokov.   

Abstract

In confirmation of recent reports, coliphages were found in seven of 19 unselected samples of the currently licensed live-virus vaccines. Coliphages and pseudomonas phage were found in 11 and 14, respectively, of the 20 bovine sera commonly used in the cell culture phase of virus vaccine production. The same lots of vaccine and serum were examined by the limulus assay for endotoxin, another product of bacterial contamination. Eighteen of 20 sera had detectable endotoxin-like activity. Our preliminary results suggest that endotoxin activity may serve as a sensitive indicator of residual products of previous bacterial contamination, including bacteriophages.

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Year:  1975        PMID： 805187     DOI： 10.1093/infdis/131.5.588

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  8 in total

1.  Elimination of bacteriophages from tissue culture serum by affinity chromatography.

Authors:  H C Orr; H H Weetall; P G Probst; D C Littlejohn; F C Chu; J B Johnson; J C Petricciani
Journal:  J Clin Microbiol       Date:  1976-04       Impact factor: 5.948

2.  Comparison of Limulus assay, standard plate count, and total coliform count for microbiological assessment of renovated wastewater.

Authors:  J H Jorgensen; J C Lee; G A Alexander; H W Wolf
Journal:  Appl Environ Microbiol       Date:  1979-05       Impact factor: 4.792

3.  A comparison of methods for detecting bacteriophage contamination of tissue culture sera.

Authors:  J A Mayo
Journal:  In Vitro       Date:  1978-05

4.  Destruction of bacterial viruses in serum by heat and radiation under conditions that sustain the ability of serum to support growth of cells in suspended culture.

Authors:  R L Ward
Journal:  J Clin Microbiol       Date:  1979-11       Impact factor: 5.948

5.  The cytogenetic, proliferative and viability effects of four bacteriophages on human lymphocytes.

Authors:  S L Wenger; J H Turner; J C Petricciani
Journal:  In Vitro       Date:  1978-06

6.  Endotoxins in commercial vaccines.

Authors:  M R Geier; H Stanbro; C R Merril
Journal:  Appl Environ Microbiol       Date:  1978-09       Impact factor: 4.792

7.  Rapid diagnosis of gram-negative bacterial meningitis by the Limulus endotoxin assay.

Authors:  J H Jorgensen; J C Lee
Journal:  J Clin Microbiol       Date:  1978-01       Impact factor: 5.948

8.  Rapid detection of bacterial endotoxins in drinking water and renovated wastewater.

Authors:  J H Jorgensen; J C Lee; H R Pahren
Journal:  Appl Environ Microbiol       Date:  1976-09       Impact factor: 4.792
  8 in total

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