Literature DB >> 8050673

Role of neurotrophins in mouse neuronal development.

R Klein1.   

Abstract

During vertebrate development, naturally occurring neuronal cell death is regulated by target-derived peptide factors, called neurotrophins. A recent series of papers describe the phenotypes of germline-targeted mutant mice deficient in neurotrophins and their receptors. Histological analysis of these mice for the first time has provided knowledge about the specific neuron populations that are dependent on neurotrophin action for development. Mice deficient for nerve growth factor (NGF) and its high-affinity receptor, encoded by the trkA proto-oncogene, suffer from complete loss of sympathetic neurons and sensory neurons responsive to temperature and pain. Mice deficient for brain-derived neurotrophic factor (BDNF) and its receptor, encoded by the trkB gene, display loss of sensory neurons responsive to tactile stimuli. In addition, trkB mutant mice experience loss of motor neurons indicating a possible specific function of the second TrkB ligand, neurotrophin-4 (NT-4), in motor neuron development. Mice deficient for neurotrophin-3 (NT-3) and its receptor, encoded by the trkC gene, show abnormal movements caused by the loss of sensory proprioceptive neurons.

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Year:  1994        PMID: 8050673     DOI: 10.1096/fasebj.8.10.8050673

Source DB:  PubMed          Journal:  FASEB J        ISSN: 0892-6638            Impact factor:   5.191


  48 in total

1.  Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis.

Authors:  M Majdan; C Lachance; A Gloster; R Aloyz; C Zeindler; S Bamji; A Bhakar; D Belliveau; J Fawcett; F D Miller; P A Barker
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

2.  Autocrine signaling by an Aplysia neurotrophin forms a presynaptic positive feedback loop.

Authors:  Iksung Jin; Hiroshi Udo; Russell Nicholls; Huixiang Zhu; Eric R Kandel; Robert D Hawkins
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-05       Impact factor: 11.205

3.  Acute morphogenic and chemotropic effects of neurotrophins on cultured embryonic Xenopus spinal neurons.

Authors:  G l Ming; A M Lohof; J Q Zheng
Journal:  J Neurosci       Date:  1997-10-15       Impact factor: 6.167

Review 4.  Motor neuron trophic factors: therapeutic use in ALS?

Authors:  Thomas W Gould; Ronald W Oppenheim
Journal:  Brain Res Rev       Date:  2010-10-21

Review 5.  Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses.

Authors:  Robert J Romanelli; Teresa L Wood
Journal:  J Neurochem       Date:  2008-06-01       Impact factor: 5.372

6.  Expression and function of TrkB variants in developing sensory neurons.

Authors:  N Ninkina; J Adu; A Fischer; L G Piñón; V L Buchman; A M Davies
Journal:  EMBO J       Date:  1996-12-02       Impact factor: 11.598

7.  Masseteric nerve injury increases expression of brain-derived neurotrophic factor in microglia within the rat mesencephalic trigeminal tract nucleus.

Authors:  Hiroyuki Ichikawa; Tadasu Sato; Mitsuhiro Kano; Toshihiko Suzuki; Saburo Matsuo; Hiroyasu Kanetaka; Yoshinaka Shimizu
Journal:  Cell Mol Neurobiol       Date:  2011-01-12       Impact factor: 5.046

8.  Epidermal growth factor receptor in adult human dorsal root ganglia.

Authors:  J J Huerta; R Diaz-Trelles; F J Naves; M M Llamosas; M E Del Valle; J A Vega
Journal:  Anat Embryol (Berl)       Date:  1996-09

9.  Null mutations of NT-3 and Bax affect trigeminal ganglion cell number but not brainstem barrelette pattern formation.

Authors:  Tony Mosconi; J J Arends; Mark F Jacquin
Journal:  Somatosens Mot Res       Date:  2013-04-24       Impact factor: 1.111

10.  Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75.

Authors:  J L Hoard; D B Hoover; A M Mabe; R D Blakely; N Feng; N Paolocci
Journal:  Neuroscience       Date:  2008-07-08       Impact factor: 3.590

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