K Wright1, S P Wright. 1. Department of Pediatrics, University of Tennessee Medical Center at Knoxville.
Abstract
OBJECTIVE: To determine if glucocorticoid therapy alters the severity of retinopathy of prematurity (ROP). DESIGN: Retrospective survey. SETTING: Tertiary intensive care nursery. PATIENTS: One hundred forty-seven surviving infants with birth weight of 1.25 kg or less born July 1990 through January 1993. OUTCOME MEASURES: Maximum stage of retinopathy and the need for cryosurgery. RESULTS: Using logistic regression, neither corticosteroid exposure nor total corticosteroid dose was associated with either ROP greater than stage 2 or cryosurgery. The significant predictors of ROP greater than stage 2 were birth weight and the duration of supplemental oxygen therapy. The only significant risk factor for cryosurgery was gestational age. CONCLUSIONS: No association between corticosteroid therapy and the severity of ROP was found after controlling for traditional risk factors such as birth weight, gestational age, and duration of supplemental oxygen therapy.
OBJECTIVE: To determine if glucocorticoid therapy alters the severity of retinopathy of prematurity (ROP). DESIGN: Retrospective survey. SETTING: Tertiary intensive care nursery. PATIENTS: One hundred forty-seven surviving infants with birth weight of 1.25 kg or less born July 1990 through January 1993. OUTCOME MEASURES: Maximum stage of retinopathy and the need for cryosurgery. RESULTS: Using logistic regression, neither corticosteroid exposure nor total corticosteroid dose was associated with either ROP greater than stage 2 or cryosurgery. The significant predictors of ROP greater than stage 2 were birth weight and the duration of supplemental oxygen therapy. The only significant risk factor for cryosurgery was gestational age. CONCLUSIONS: No association between corticosteroid therapy and the severity of ROP was found after controlling for traditional risk factors such as birth weight, gestational age, and duration of supplemental oxygen therapy.
Authors: Sang Jin Kim; Alexander D Port; Ryan Swan; J Peter Campbell; R V Paul Chan; Michael F Chiang Journal: Surv Ophthalmol Date: 2018-04-19 Impact factor: 6.048