Literature DB >> 8043031

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver.

J Hakkola1, M Pasanen, R Purkunen, S Saarikoski, O Pelkonen, J Mäenpää, A Rane, H Raunio.   

Abstract

Expression of human cytochrome P450 (CYP) genes in human adult and fetal liver were studied using the reverse transcriptase-polymerase chain reaction (RT-PCR) method. In adult liver mRNA of CYPs 1A1, 1A2, 2A6/2A7, 2B6/2B7, 2C8-19, 2D6, 2E1, 3A3/3A4 and 3A7 were detected while CYPs 2F1 and 4B1 were absent. In fetal liver mRNA of CYPs 2C8, 2D6, 3A3/3A4 and 3A7 were found but all other forms studied were undetectable. The results provide a comprehensive qualitative picture of the expression of CYP genes in families CYP1 through CYP4 in human adult and fetal liver.

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Year:  1994        PMID： 8043031     DOI： 10.1016/0006-2952(94)90223-2

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


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