Enhanced gastric acid secretion induced by gastrin can be suppressed by glucose injected into the portal vein in rats.

Gastric acid secretion induced by tetragastrin was examined after glucose injection into the portal vein in rats. The enhancement of acid secretion caused by gastrin was inhibited by glucose injection into the portal vein, and the acid response was dose dependent. The acid response due to portal glucose injection was not reproduced when the hepatic vagal branch was sectioned. These findings suggest that the portal glucose signal modulates gastric acid secretion controlled by gastrin.