| Literature DB >> 8043011 |
C Perigaud1, A M Aubertin, S Benzaria, H Pelicano, J L Girardet, G Maury, G Gosselin, A Kirn, J L Imbach.
Abstract
It is shown that ddA bis(SATE)phosphotriester is one of the most potent anti-HIV agents in cell culture. Compared with the parent nucleoside, ddA, an increase of 3 orders of magnitude was observed in the EC50, which makes this compound as active as AZT. This can be tentatively explained if one considers that direct ddAMP intracellular delivery shunts the well established ddA/ddI metabolism pathway.Entities:
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Year: 1994 PMID： 8043011 DOI： 10.1016/0006-2952(94)90217-8
Source DB: PubMed Journal: Biochem Pharmacol ISSN： 0006-2952 Impact factor: 5.858